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Publication Date:
June 2007
ISSN:
1569-3945
DOI:
10.1515/jiip.2007.013

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Editor-in-Chief: Kabanikhin, Sergey I.

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Sensitivity analysis and parameter estimation for a model of Chlamydia Trachomatis infection

J. A. Burns / E. M. Cliff / S. E. Doughty

1Interdisciplinary Center for Applied Mathematics, Virginia Polytechnic Institute and State University, West Campus Drive, Blacksburg, VA 24061, USA. Email: burns@math.vt.edu

1Interdisciplinary Center for Applied Mathematics, Virginia Polytechnic Institute and State University, West Campus Drive, Blacksburg, VA 24061, USA. Email: ecliff@vt.edu

1Department of Neuroscience, Vanderbilt University, Nashville, TN 37235, USA. Email: sabrina.e.doughty@vanderbilt.edu

Citation Information: Journal of Inverse and Ill-posed Problems jiip. Volume 15, Issue 3, Pages 243–256, ISSN (Online) 1569-3953, ISSN (Print) 0928-0219, DOI: 10.1515/jiip.2007.013, June 2007

Publication History:
Published Online:
2007-06-25

In this paper we consider a parameter estimation problem for delay differential equations that are typical in the bioscience. The problem is motivated by a model of the dynamics of the intracellular development cycle of Chlamydia Trachomatis and can be formulated as a inverse problem for a system of delay equations. We derive the continuous sensitivity equations and show that the corresponding initial value problem is well-posed. The sensitivity equations are used to compute gradients in the optimization loop for the parameter estimation problem. Numerical examples are given to illustrate the key ideas and we close with a note about the use of continuous sensitivity equations in the design of experiments.

Key Words: Delay equations,; sensitivity analysis,; parameter estimation.

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