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Publication Date:
August 2005
ISSN:
1619-3997
DOI:
10.1515/JPM.2005.056

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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

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The transcription factor Ets-1 is expressed in human amniochorionic membranes and is up-regulated in term and preterm premature rupture of membranes

Silké A.M. Michaelis1 / Ali Fuat Okuducu2 / Nanette M.E. Sarioglu3 / Andreas von Deimling4 / Joachim W. Dudenhausen5

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Corresponding author: Silké A.M. Michaelis, MD, MRCOG Klinik für Geburtsmedizin Charité–Universitätsmedizin Berlin Campus Virchow–Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany, Tel.: +49-30-450564072 Fax: +49-30-450564901

Citation Information: Journal of Perinatal Medicine. Volume 33, Issue 4, Pages 314–319, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2005.056, August 2005

Publication History:
Received:
November 19, 2004
Revised:
February 25, 2005
Accepted:
April 1, 2005
Published Online:
2005-08-10

Abstract

Objective: The major tensile strength of fetal membranes is provided by their extracellular matrix (ECM) components. The transcription factor Ets-1 is a critical mediator of ECM remodelling. The purpose of this study was to examine whether Ets-1 is expressed in human fetal membranes and whether it is implicated in premature membrane rupture.

Study design: Amniochorionic membranes from 52 women in the following categories were analyzed for Ets-1 expression: preterm and term premature rupture of membranes, preterm and term labor and delivery, and preterm and term cesarean sections without previous onset of labor. Ets-1 protein was localized with the use of immunohistochemistry. Ets-1 levels were determined with a histoscore.

Results: Ets-1 protein was localized to the trophoblast as well as to the stromal layers. Ets-1 protein expression was up-regulated in the stroma of term and preterm prematurely ruptured membranes.

Conclusion: Ets-1 is expressed in human fetal membranes and its expression is up-regulated with premature rupture of membranes, suggesting a role for Ets-1 in ECM remodelling of the membranes.

Keywords: Transcription factors; fetal membranes; premature rupture of the membranes; preterm delivery

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