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Publication Date:
February 2010
ISSN:
1619-3997
DOI:
10.1515/jpm.2010.021

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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Aslam, Muhammad / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Brezinka, Christoph / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / Dimitrou, G. / Foulon, Walter / Grunebaum, G. E. / Harding, Jane / Hentschel, Roland / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Nishida, Hiroshi / Papp, Zoltán / Makatsariya, Alexander / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Geijn, Herman P. / Vetter, Klaus / Young, Bruce K. / Zimmermann, Roland / Köpcke, W.

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Intracerebral transplantation of mesenchymal stem cells derived from human umbilical cord blood alleviates hypoxic ischemic brain injury in rat neonates

Guizhi Xia1 / Xinru Hong2 / Xinmin Chen2 / Fenghua Lan3 / Guocheng Zhang1 / Lianming Liao4

1Department of Pediatrics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China

2The Institute of Child Health of PLA, Fuzhou General Hospital, Fuzhou, China

3Center for Molecular Medicine, Fuzhou General Hospital, Fuzhou, China

4Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Corresponding authors: Guocheng Zhang Department of Pediatrics Xijing Hospital The Fourth Military Medical University Xi'an 710032 China Tel.: +86-29-8477-5395 (Office) Fax: +86-29-8477-3306 Xinru Hong The Institute of Child Health of PLA Fuzhou General Hospital Fuzhou 350025 China Tel.: +86-591-2285-9200 (Office)/+86-591-8379-3257 (Home) Fax: +86-591-3812-1219

Citation Information: Journal of Perinatal Medicine. Volume 38, Issue 2, Pages 215–221, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/jpm.2010.021, February 2010

Publication History:
Received:
2009-03-21
Revised:
2009-08-05
Accepted:
2009-11-13
Published Online:
2010-02-02

Abstract

Aims: Fetal hypoxic-ischemic brain injury (HIBI) is a severe condition for which no effective therapy exists. In this study mesenchymal stem cells (MSCs) from human umbilical cord blood (UCB) of full-term newborns were isolated and intracerebrally transplanted into rat neonates after HIBI induction. Nerve function was assessed by the modified neurological severity scores (mNSS) to establish if MSCs could alleviate nerve injury.

Results: Immunostaining showed the transplanted MSCs migrated to the hippocampus. Rats receiving MSCs treatment showed significant improvement in the mNSS when compared with controls. Also, histochemical study showed alleviation of brain tissue injury after MSCs treatment. Differentiation of MSCs to astrocytes, but not neurons, was observed.

Conclusions: The results indicate a beneficial effect of intracerebral transplantation of MSCs on the functional recovery of rat neonates with HIBI.

Keywords: Cord blood; fetal hypoxic-ischemic brain injury; mesenchymal stem cells

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