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Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

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Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

Anwar Shaikh1 / Rajani Giridhar1 / Francis Megraud1 / Mange Yadav1

Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390001, India1

Laboratoire de Bacteriologie, Université Victor Segalen Bordeaux 2 and Hôpital Pellegrin, Place Amélie Raba-Léon 33076 Bordeaux cedex France2

This content is open access.

Citation Information: Acta Pharmaceutica. Volume 59, Issue 3, Pages 259–271, ISSN (Online) 1846-9558, ISSN (Print) 1330-0075, DOI: 10.2478/v10007-009-0027-6, October 2009

Publication History

Published Online:
2009-10-09

Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

Novel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with bismuth. The complexes were characterized by UV, IR, atomic absorption spectroscopy, elemental analysis, differential scanning calorimetry, thermogravimetric analysis and mass spectrometry. Their antibacterial potential against Helicobacter pylori and other microorganisms was investigated. These compounds were found to possess strong activity against Helicobacter pylori with a minimum inhibitory concentration of 0.5 mg L-1. They also exhibited moderate activity against Escherichia coli, Staphylococcus aureus, Bacillus pumilus and Staphylococcus epidermidis. These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H. pylori related ailments.

Metaloantibiotici: Sinteza, karakterizacija i antimikrobno djelovanje kompleksa fluorokinolona s bizmutom na Helicobacter pylori

Komplesacijom fluorokinolona, norfloksacina, ofloksacina, ciprofloksacina, sparfloksacina, lomefloksacina, pefloksacina i gatifloksacina s bizmutom pripravljeni su novi organometalni spojevi. Dobiveni kompleksi karakterizirani su UV, IR i atomskom apsorpcijskom spektroskopijom, elementarnom analizom, diferencijalnom pretražnom kalorimetrijom, termogravimetrijskom analizom i spektrometrijom masa. Nadalje, ispitivan je njihov učinak na Helicobacter pylori i druge mikroorganizme. Ispitivani spojevi pokazuju snažno djelovanje na Helicobacter pylori u koncentraciji 0,5 mg L-1 te umjereno djelovanje na Escherichia coli, Staphylococcus aureus, Bacillus pumilus i Staphylococcus epidermidis. Kompleksi fluorokinolona s bizmutom potencijalni su lijekovi za infekcije uzrokovane H. pylori.

Keywords: fluoroquinolone; bismuth; complex; antimicrobial activity; Helicobacter pylori

Keywords: fluorokinolon; bizmut; kompleks; antimikrobno djelovanje; Helicobacter pylory

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