Jump to ContentJump to Main Navigation

Advances in Medical Sciences

The Journal of Medical University of Bialystok

2 Issues per year

IMPACT FACTOR 2012: 0.796
5-year IMPACT FACTOR: 1.094

Open Access

Open Access

The influence of Chlamydia trachomatis infection on spontaneous abortions

M Wilkowska-Trojniel1 / B Zdrodowska-Stefanow1 / I Ostaszewska-Puchalska1 / S Redźko1 / J Przepieść1 / M Zdrodowski1

Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland1

Centre for STD Research and Diagnostics, Bialystok, Poland2

Department of Perinatology, Medical University of Bialystok, Bialystok, Poland3

Department of Gynecology, Medical University of Bialystok, Bialystok, Poland4

This content is open access.

Citation Information: Advances in Medical Sciences. Volume 54, Issue 1, Pages 86–90, ISSN (Online) 1898-4002, ISSN (Print) 1896-1126, DOI: 10.2478/v10039-009-0008-5, April 2009

Publication History

Published Online:

The influence of Chlamydia trachomatis infection on spontaneous abortions

Purpose: The aim of the study was to evaluate the frequency of Chlamydia trachomatis (C.t.) infection among women who experienced a miscarriage.

Materials and Methods: Patients referred to the Centre for STD Research and Diagnostics in Bialystok from the Department of Perinatology and from gynaecological outpatient clinics, after spontaneous abortion were enrolled in the study. C.t. infection diagnostics were performed among 76 women with 1 miscarriage and 44 patients with ≥2 miscarriages in anamnesis. Forty-six patients in the 2nd and the 3rd trimester of normal pregnancy served as a comparative group. Endocervical swabs as well as blood serum were obtained. To detect chlamydial DNA, direct PCR method was performed (Roche, Molecular Systems, N.J., USA). To detect IgA and IgG specific anti-chlamydial antibodies we used immunoenzymatic assay (medac, Hamburg, Germany).

Results: In patients with 1 miscarriage (gr.1), C.t. infection by means of PCR was detected in 11.8% of women (p=0.029), in patients with ≥2 miscarriages (gr.2) in 9.1% (p=0.198) and in the comparative group (gr.0) in 2.2%. Specific anti-chlamydial antibodies IgA class were detected in: 7.9 (p=0.082) in group 1, 4.5% (p=0.236) in group 2 and in 0% in group 0, and IgG class in 21.1% (p=0.024), 36.4% (p=0.000) and in 4.4%, respectively.

Conclusions: 1. C.t. infection is an important causative agent of miscarriages in women. 2. C.t. infection diagnostic procedures should be considered in screening tests during pregnancy.

Keywords: Chlamydia trachomatis; miscarriage; recurrent spontaneous abortions; specific anti-chlamydial antibodies

  • Centers for Disease Control and Prevention [Internet]. Sexually Transmitted Disease Surveillance 2007, Chlamydia Prevalence Monitoring Project Annual Report - 2007, Atlanta, GA (USA). [cited 2009 Apr 3]. Available from: http://www.cdc.gov/std/Chlamydia2007/

  • Rastogi S, Salhan S, Mittal A. Detection of Chlamydia trachomatis antigen in spontaneous abortions. Is this organism a primary or secondary indicator of risk? Br J Biomed Sci. 2000; 57(2):126-9. [PubMed]

  • Thomas GB, Jones J, Sbarra AJ, Cetrulo C, Reisner D. Isolation Chlamydia trachomatis from amniotic fluid. Obstet Gynecol. 1990 Sep;76(3Pt2):519-20.

  • Harrison HR, Riggin RT. Infection of untreated primary human amnion monolayer with Chlamydia trachomatis. J Infect Dis. 1979 Dec;140(6):968-71.

  • Neeper ID, Patton DL, Kuo CC. Cinematographic observations of growth cycles of Chlamydia trachomatis in primary cultures of human amniotic cells. Infect Immun. 1990 Jul;58(7):2042-7.

  • Schwarz BE, Schultz FM, MacDonald PC, Johnston JM. Initiation of human parturition. IV. Demonstration of phospholipase A2 in the lysosomes of human fetal membranes. Am J Obstet Gynecol. 1976 Aug 15;125(8):1089-92.

  • Elias M, Choroszy-Król I. Chlamydia trachomatis during genital tract infection and in imminent abortion. Ginekol Pol. 1995 Sep;66(9):513-7.

  • Dudkiewicz J, Donhoeffner B. Wpływ Chlamydia trachomatis i innych bakterii na przebieg ciąży. In: Materiały naukowe na 24 Krajowy Kongres Polskiego Towarzystwa Ginekologicznego; 1991 May; Poznan, Poland. Ginekol Pol. 1991; Suppl.1:340-3.

  • Choroszy-Król I, Teryks-Wołyniec M, Frej-Mądrzak M, Gryboś M., editors. Chlamydia trachomatis w zakażeniach układu moczowo-płciowego u kobiet. Proceedings of the XXV Jubileuszowy Zjazd Polskiego Towarzystwa Mikrobiologicznego; 2004 September 23-25; Bydgoszcz, Poland. Post Mikrobiol. 2004,43; Suppl.1:130.

  • Zgórniak-Nowosielska I, Sławińska B, Szostek S, Zawilińska B. Chorobotwórczość i metody rozpoznawania zakażeń narządu moczowo-płciowego, wywołanych przez Chlamydia trachomatis. Mikrob Med. 1996;3(8): 3-7.

  • Quinn PA, Petric M, Barkin M, Butany J, Derzko C, Gysler M, Lie KI, Shewchuck AB, Shuber J, Ryan E. Prevalence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility. Am J Obstet Gynecol. 1987 Feb;156(2):291-6.

  • Witkin SS, Ledger WJ. Antibodies to Chlamydia trachomatis in sera of women with recurrent spontaneous abortions. Am J Obstet Gynecol. 1992 Jul;167(1):135-9.

  • Rae R, Smith IW, Liston WA, Kilpatrick DC. Chlamydial serologic studies and recurrent spontaneous abortion. Am J Obstet Gynecol. 1994 Mar;170(3):782-5.

  • Paukku M, Tulppala M, Puolakkainen M, Anttila T, Paavonen J. Lack of association between serum antibodies to Chlamydia trachomatis and a history of recurrent pregnancy loss. Fertil Steril. 1999 Sep;72(3):427-30.

  • Osser S, Persson K. Chlamydial antibodies in women who suffer miscarriage. Br J Obstet Gynaecol. 1996 Feb;103(2):137-41.

  • Sozio J, Ness RB. Chlamydial lower genital tract infection and spontaneous abortion. Infect Dis Obstet Gynecol. 1998;6(1):8-12. [PubMed]

Comments (0)

Please log in or register to comment.