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Advances in Medical Sciences

The Journal of Medical University of Bialystok

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Extrahepatic manifestations associated with chronic hepatitis C infections in Poland

D Zarebska-Michaluk1 / D Lebensztejn1 / W Kryczka1, / E Skiba1,

Department of Infectious Diseases, Provincial Hospital, Kielce, Poland1

Department of Pediatrics, Gastroenterology and Allergology, Medical University of Bialystok, Bialystok, Poland2

Institute of Medical Education, Swietokrzyska Academy, Kielce, Poland3

Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland4

This content is open access.
(CC BY-NC-ND 4.0)

Citation Information: Advances in Medical Sciences. Volume 55, Issue 1, Pages 67–73, ISSN (Online) 1898-4002, ISSN (Print) 1896-1126, DOI: 10.2478/v10039-010-0009-4, April 2010

Publication History:
Published Online:
2010-04-06

Extrahepatic manifestations associated with chronic hepatitis C infections in Poland

Purpose: To assess the prevalence and predictive factors of extrahepatic manifestation (EM) in patients with chronic hepatitis C (CHC) infection in Poland.

Material and Methods: 340 consecutive patients (mean age: 42 years) with untreated CHC were studied between 2000 and 2006. The HCV infection was defined by positive serology and serum HCV RNA. The inflammation grade and fibrosis stage were assessed according to Ishak. Demographic, laboratory and liver biopsy data were collected. The patients with liver cirrhosis, concomitant HBV or HIV infection, autoimmune liver diseases and alcohol abusers were excluded from the analysis.

Results: 210 patients with CHC (61.7%) presented at least 1 extrahepatic manifestation, including mixed cryoglobulinemia (37.1%), thrombocytopenia (27.6%), thyroid autoimmunity (16.2%), dermatological disorders (4.1%) and type 2 diabetes (4.1%). Other EM such as the sicca syndrome, nephropathy, polyneuropathy and B-cell lymphoma were observed in single cases. In multivariate analysis lower platelet count was found as a predictive factor of EM in patients with CHC.

Conclusions: The majority of patients with CHC, living in Poland, have EM, of which cryoglobulinemia, thrombocytopenia, thyroid autoimmunity, dermatological disorders and type 2 diabetes are most common. Through the multivariate analysis the lower platelet predicts extrahepatic manifestations associated with chronic hepatitis C.

Keywords: hepatitis C; extrahepatic manifestation; cryoglobulinemia; thrombocytopenia; thyroid autoimmunity

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