Jump to ContentJump to Main Navigation

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR increased in 2014: 3.268
Rank 106 out of 289 in category Biochemistry & Molecular Biology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.596
Source Normalized Impact per Paper (SNIP) 2014: 0.845
Impact per Publication (IPP) 2014: 2.992

VolumeIssuePage

Issues

Secretory Immunoglobulin A: from Mucosal Protection to Vaccine Development

Blaise Corthésy / François Spertini

Citation Information: Biological Chemistry. Volume 380, Issue 11, Pages 1251–1262, ISSN (Print) 1431-6730, DOI: 10.1515/BC.1999.160, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Immune responses taking place in mucosal tissues are typified by secretory immunoglobulin A (S-IgA) molecules, which are assembled from proteins expressed in two cell lineages. The heavy and light chains as well as the J chain are produced in plasma cells, whereas the secretory component (SC) is associated to the immunoglobulin complex during transcytosis across the epithelial layer. S-IgA antibodies represent the predominant immunoglobulin class in external secretions, and the best defined entity providing specific immune protection for mucosal surfaces by blocking attachment of bacteria and viruses. S-IgA constitutes greater than 80% of all antibodies produced in mucosa-associated lymphoid tissues in humans. The existence of a common mucosal immune system permits immunization on one mucosal surface to induce secretion of antigen-specific S-IgA at distant sites. In addition, S-IgA antibodies not only function in external secretions, but also exert their antimicrobial properties within the epithelial cell during transport across the epithelium. Passive mucosal delivery of monoclonal IgA molecules neutralizes pathogens responsible for gastrointestinal and respiratory infections. Mucosal and systemic immunity can be achieved by orally administered recombinant S-IgA molecules carrying a protective bacterial epitope within the SC polypeptide primary sequence.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Kristof Moonens, Imke Van den Broeck, Emmanuel Okello, Els Pardon, Maia De Kerpel, Han Remaut, and Henri De Greve
Veterinary Research, 2015, Volume 46, Number 1, Page 14
[2]
Raul Rojas and Gerard Apodaca
Nature Reviews Molecular Cell Biology, 2002, Volume 3, Number 12, Page 944
[3]
David Reinhart and Renate Kunert
Biotechnology Letters, 2015, Volume 37, Number 2, Page 241
[4]
Zhuo Liu, Patrick V. Gurgel, and Ruben G. Carbonell
Biotechnology Progress, 2013, Volume 29, Number 1, Page 91
[5]
Ningguo Feng, Jeffrey A. Lawton, Joana Gilbert, Nelly Kuklin, Phuoc Vo, B.V. Venkataram Prasad, and Harry B. Greenberg
Journal of Clinical Investigation, 2002, Volume 109, Number 9, Page 1203
[7]
Willemien H. Wieland, Diego Orzáez, Aart Lammers, Henk K. Parmentier, and Arjen Schots
Veterinary Immunology and Immunopathology, 2006, Volume 110, Number 1-2, Page 129
[8]
Takeshi Nikawa, Madoka Ikemoto, Mihoko Kano, Kaori Tokuoka, Katsuya Hirasaka, Shoji Uehara, Kiyoshi Takatsu, Kazuhito Rokutan, and Kyoichi Kishi
Biochemical and Biophysical Research Communications, 2001, Volume 285, Number 2, Page 546
[9]
Ianko D. Iankov, Dragomir P. Petrov, Ivan V. Mladenov, Iana H. Haralambieva, Ognian K. Kalev, Maria S. Balabanova, and Ivan G. Mitov
Microbes and Infection, 2004, Volume 6, Number 10, Page 901
[10]
Laurent I. Favre, François Spertini, and Blaise Corthésy
Journal of Chromatography B, 2003, Volume 786, Number 1-2, Page 143
[11]
Regina Célia de Souza Campos Fernandes, Victor Martin Quintana Flores, Zila Sousa de Macedo, and Enrique Medina-Acosta
Vaccine, 2003, Volume 21, Number 15, Page 1725
[12]
Arnaud Debin, Roger Kravtzoff, Jocelyn Vaz Santiago, Laurence Cazales, Sandrine Sperandio, Karl Melber, Zbigniew Janowicz, Didier Betbeder, and Marinette Moynier
Vaccine, 2002, Volume 20, Number 21-22, Page 2752
[13]
K.C. Carter, V.A. Ferro, J. Alexander, and A.B. Mullen
Methods, 2006, Volume 38, Number 2, Page 65
[14]
Michael Dechant and Thomas Valerius
Critical Reviews in Oncology/Hematology, 2001, Volume 39, Number 1-2, Page 69
[15]
Fangbing Liu, Pablo Lopez Bergami, Mark Duval, David Kuhrt, Marshall Posner, and Lisa Cavacini
AIDS Research and Human Retroviruses, 2003, Volume 19, Number 7, Page 597
[16]
Joseph U Igietseme, Francis O Eko, Qing He, and Carolyn M Black
Expert Review of Vaccines, 2004, Volume 3, Number 1, Page 23
[17]
Diego Orzáez, Antonio Granell, and Miguel A. Blázquez
Biotechnology Journal, 2009, Volume 4, Number 12, Page 1712
[18]
Ningguo Feng, Jeffrey A. Lawton, Joana Gilbert, Nelly Kuklin, Phuoc Vo, B.V. Venkataram Prasad, and Harry B. Greenberg
Journal of Clinical Investigation, 2002, Volume 109, Number 9, Page 1203
[20]
Salvatore Grosso, Maddalena Cioni, Gianluca Garibaldi, Lucia Pucci, Paolo Galluzzi, Raffaello Canapicchi, Guido Morgese, and Paolo Balestri
American Journal of Medical Genetics, 2002, Volume 112, Number 1, Page 56

Comments (0)

Please log in or register to comment.