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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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The Human Cathepsin F Gene a Fusion Product between an Ancestral Cathepsin and Cystatin Gene

Thomas Wex / Heike Wex / Dieter Brömme

Citation Information: Biological Chemistry. Volume 380, Issue 12, Pages 1439–1442, ISSN (Print) 1431-6730, DOI: 10.1515/BC.1999.185, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Human cathepsin F is a novel papain-like cysteine protease of unknown function. Here, we describe the complete human cathepsin F (CTSF) gene which is composed of 13 exons. In addition to a previous report, two novel upstream located exons whose splice sites interrupted the propeptide of cathepsin F within the ‘cystatin-like’ domain, recently described by Nagler et al. (Biochem. Biophys. Res. Comm. 257, 313–318, 1999) were identified. A comparison of the genomic structures between this novel part of the cathepsin F gene and those of several cystatin genes revealed striking similarities, supporting the hypothesis that the cathepsin F gene resulted from a gene fusion between an ancestral cystatin and cathepsin gene.

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