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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Activation of the Transcription Factor ISGF3 by Interferon-gamma

M. Matsumoto / N. Tanaka / H. Harada / T. Kimura / T. Yokochi / M. Kitagawa / C. Schindler / T. Taniguchi

Citation Information: Biological Chemistry. Volume 380, Issue 6, Pages 699–703, ISSN (Print) 1431-6730, DOI: 10.1515/BC.1999.087, June 2005

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The interferon-stimulated gene factor 3 (ISGF3) transcription factor has been extensively studied in the context of the type I interferon (IFN-α/β)-mediated antiviral response; it consists of the major DNA-binding component p48, and the signal transducers and activators of transcription (Stat)1 and Stat2. We show here that type II IFN (IFN-γ) can also invoke the activation of ISGF3 in mouse primary embryonic fibroblasts. In fact, the two Stat proteins were tyrosine phosphorylated in IFN-γ stimulated cells. Our present findings reveal an additional mechanism by which these two distinct types of cytokines, IFN-α/β and -γ, can commonly elicit antiviral activities.

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