Jump to ContentJump to Main Navigation

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR increased in 2014: 3.268
Rank 106 out of 289 in category Biochemistry & Molecular Biology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.596
Source Normalized Impact per Paper (SNIP) 2014: 0.845
Impact per Publication (IPP) 2014: 2.992



Oxidative Nerve Cell Death in Alzheimers Disease and Stroke: Antioxidants as Neuroprotective Compounds

C. Behl / B. Moosmann

Citation Information: Biological Chemistry. Volume 383, Issue 3-4, Pages 521–536, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2002.053, June 2005

Publication History

Published Online:


Many neurodegenerative disorders and syndromes are associated with an excessive generation of reactive oxygen species (ROS) and oxidative stress. The pathways to nerve cell death induced by diverse potential neurotoxins such as peptides, excitatory amino acids, cytokines or synthetic drugs commonly share oxidative downstream processes, which can cause either an acute oxidative destruction or activate secondary events leading to apoptosis. The pathophysiological role of ROS has been intensively studied in in vitro and in vivo models of chronic neurodegenerative diseases such as Alzheimers disease (AD) and of syndromes associated with rapid nerve cell loss as occuring in stroke. In AD, oxidative neuronal cell dysfunction and cell death caused by protofibrils and aggregates of the ADassociated amyloid β protein (Aβ) may causally contribute to pathogenesis and progression. ROS and reactive nitrogen species also take part in the complex cascade of events and the detrimental effects occuring during ischemia and reperfusion in stroke. Direct antioxidants such as chainbreaking free radical scavengers can prevent oxidative nerve cell death. Although there is ample experimental evidence demonstrating neuroprotective activities of direct antioxidants in vitro, the clinical evidence for antioxidant compounds to act as protective drugs is relatively scarce. Here, the neuroprotective potential of antioxidant phenolic structures including αtocopherol (vitamin E) and 17βestradiol (estrogen) in vitro is summarized. In addition, the antioxidant and cytoprotective activities of lipophilic tyrosine and tryptophancontaining structures are discussed. Finally, an outlook is given on the neuroprotective potential of aromatic amines and imines, which may comprise novel lead structures for antioxidant drug design.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Victor Hernandez-Olmos, Aliaa Abdelrahman, Ali El-Tayeb, Diana Freudendahl, Stephanie Weinhausen, and Christa E. Müller
Journal of Medicinal Chemistry, 2012, Volume 55, Number 22, Page 9576
Zhiyou Cai and Ming Xiao
International Journal of Neuroscience, 2015, Page 1
Jean Radom, Didier Colin, Franck Thiebault, Mai Dognin-Bergeret, Georges Mairet-Coello, Annick Esnard-Feve, Dominique Fellmann, and Michèle Jouvenot
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2006, Volume 1759, Number 5, Page 225
Hyung-Jin Kim, Gi-Su Oh, AiHua Shen, Su-Bin Lee, Dipendra Khadka, Arpana Pandit, Hyeok Shim, Sei-Hoon Yang, Eun-Young Cho, Jeho Song, Tae Hwan Kwak, Seong-Kyu Choe, Raekil Park, and Hong-Seob So
Hearing Research, 2015, Volume 326, Page 30
Jung Eun Hwang, Joon-Woo Ahn, Soon-Jae Kwon, Jin-Baek Kim, Sang Hoon Kim, Si-Yong Kang, and Dong Sub Kim
Molecular Biology Reports, 2014, Volume 41, Number 11, Page 7671
Andréa G.K. Ferreira, Emilene B. Scherer, Aline A. da Cunha, Vanusa Manfredini, Giovana Brondani Biancini, Camila Simioni Vanzin, Carmen R. Vargas, and Angela T.S. Wyse
The International Journal of Biochemistry & Cell Biology, 2014, Volume 54, Page 20
Jie Li, Wuliji O, Wei Li, Zhi-Gang Jiang, and Hossein Ghanbari
International Journal of Molecular Sciences, 2013, Volume 14, Number 12, Page 24438
Alexander Brendel, Jana Renziehausen, Christian Behl, and Parvana Hajieva
NeuroToxicology, 2014, Volume 40, Page 43
D. W. Walker and S. Benzer
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 28, Page 10290
Marcia Gilceane Cardozo, Niara Medeiros, Denise dos Santos Lacerda, Daniela Campos de Almeida, João Antônio Pegas Henriques, Caroline Dani, and Cláudia Funchal
Cellular and Molecular Neurobiology, 2013, Volume 33, Number 8, Page 1123
Juliana Noguti, Monica Levy Andersen, Chiara Cirelli, and Daniel Araki Ribeiro
Sleep and Breathing, 2013, Volume 17, Number 3, Page 905
Holger Steinbrenner and Helmut Sies
Archives of Biochemistry and Biophysics, 2013, Volume 536, Number 2, Page 152
Chi-Un Pae, Jung-Jin Kim, Soo-Jung Lee, Chang-Uk Lee, Chul Lee, In-Ho Paik, Ho-Ran Park, Soo Yang, and Alessandro Serretti
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003, Volume 27, Number 3, Page 519
Rongcai Yue, Xing Yuan, Xiaojun Liu, Jigang Zhang, Peng Jiang, Cheng He, Lei Shan, Yizhi Yu, and Weidong Zhang
Journal of Neurochemistry, 2012, Volume 121, Number 3, Page 451
Anelise M. Tonin, Mateus Grings, Lisiane A. Knebel, Ângela Zanatta, Alana P. Moura, César A.J. Ribeiro, Guilhian Leipnitz, and Moacir Wajner
International Journal of Developmental Neuroscience, 2012, Volume 30, Number 5, Page 383
Maike J. Ohlow, Matthias Granold, Mathias Schreckenberger, and Bernd Moosmann
FEBS Letters, 2012, Volume 586, Number 6, Page 711
Martin Ebinger, Christian Behl, Marcus Rosenhagen, and Manfred Uhr
Neuroscience Letters, 2007, Volume 427, Number 1, Page 6
Zhiyou Cai, Bin Zhao, and Anna Ratka
NeuroMolecular Medicine, 2011, Volume 13, Number 4, Page 223
Guilhian Leipnitz, Bianca Seminotti, Carolina G. Fernandes, Alexandre U. Amaral, Ana Paula Beskow, Lucila de B. da Silva, Ângela Zanatta, César A.J. Ribeiro, Carmen R. Vargas, and Moacir Wajner
International Journal of Developmental Neuroscience, 2009, Volume 27, Number 4, Page 351
Bianca Seminotti, Guilhian Leipnitz, Alexandre U. Amaral, Carolina G. Fernandes, Lucila de Bortoli da Silva, Anelise Miotti Tonin, Carmen R. Vargas, and Moacir Wajner
International Journal of Developmental Neuroscience, 2008, Volume 26, Number 7, Page 693
Jordana Penz, Tanise Gemelli, Carlos Augusto Souza Carvalho, Robson Brum Guerra, Lívia Oliboni, Mirian Salvador, Caroline Dani, Alex Sander Araújo, and Cláudia Funchal
Food and Chemical Toxicology, 2009, Volume 47, Number 4, Page 745
L.W. Fan, L.T. Tien, B. Zheng, Y. Pang, P.G. Rhodes, and Z. Cai
Neuroscience, 2010, Volume 168, Number 1, Page 240
Lucila de Bortoli da Silva, Guilhian Leipnitz, Bianca Seminotti, Carolina G. Fernandes, Ana Paula Beskow, Alexandre U. Amaral, and Moacir Wajner
Brain Research, 2009, Volume 1256, Page 34
T.T. Hong Duong, Shane Antao, Natasha A. Ellis, Simon J. Myers, and Paul K. Witting
Brain Research, 2008, Volume 1219, Page 8
Deborah Blacker
New England Journal of Medicine, 2005, Volume 352, Number 23, Page 2439
César Augusto João Ribeiro, Fernanda Hermes Hickmann, and Moacir Wajner
International Journal of Developmental Neuroscience, 2011, Volume 29, Number 1, Page 1
Guilhian Leipnitz, Bianca Seminotti, Alexandre U. Amaral, Giorgia de Bortoli, Alexandre Solano, Patrícia F. Schuck, Ângela T.S. Wyse, Clóvis M.D. Wannmacher, Alexandra Latini, and Moacir Wajner
Life Sciences, 2008, Volume 82, Number 11-12, Page 652
Maria Koufaki, Christina Kiziridi, Faidra Nikoloudaki, and Michael N. Alexis
Bioorganic & Medicinal Chemistry Letters, 2007, Volume 17, Number 15, Page 4223
Christian Behl
The Journal of Steroid Biochemistry and Molecular Biology, 2002, Volume 83, Number 1-5, Page 195
Henrik Johansson, Olov Svartström, Prasad Phadnis, Lars Engman, and Marjam Karlsson Ott
Bioorganic & Medicinal Chemistry, 2010, Volume 18, Number 5, Page 1783
G. J. Moon, D. H. Shin, D. S. Im, O. Y. Bang, H. S. Nam, J. H. Lee, I. S. Joo, K. Huh, and B. J. Gwag
European Journal of Neurology, 2011, Volume 18, Number 9, Page 1151
S R L Stacpoole, B Bilican, D J Webber, A Luzhynskaya, X L He, A Compston, R Karadottir, R J M Franklin, and S Chandran
Nature Protocols, 2011, Volume 6, Number 8, Page 1229
Vinod Tiwari, Anurag Kuhad, and Kanwaljit Chopra
Behavioural Brain Research, 2009, Volume 203, Number 2, Page 296
D. Allan Butterfield and Rukhsana Sultana
Journal of Amino Acids, 2011, Volume 2011, Page 1
Anelise M. Tonin, Mateus Grings, Estela N.B. Busanello, Alana P. Moura, Gustavo C. Ferreira, Carolina M. Viegas, Carolina G. Fernandes, Patrícia F. Schuck, and Moacir Wajner
Neurochemistry International, 2010, Volume 56, Number 8, Page 930
Hiroshi Koyama, Rizky Abdulah, Takayoshi Ohkubo, Yutaka Imai, Hiroshi Satoh, and Kenichi Nagai
Nutrition Research, 2009, Volume 29, Number 2, Page 94
Michael F. O'Neill
Drug Discovery Today, 2005, Volume 10, Number 20, Page 1333
S R L Stacpoole, B Bilican, D J Webber, A Luzhynskaya, X L He, A Compston, R Karadottir, R J M Franklin, and S Chandran
Cell Death and Differentiation, 2011, Volume 18, Number 6, Page 1016
Okezie I. Aruoma, Theeshan Bahorun, and Ling-Sun Jen
Mutation Research/Reviews in Mutation Research, 2003, Volume 544, Number 2-3, Page 203
Sandra J. Hewett, Stanley C. Bell, and James A. Hewett
Pharmacology & Therapeutics, 2006, Volume 112, Number 2, Page 335
Kelley A. Foster, Francesca Galeffi, Florian J. Gerich, Dennis A. Turner, and Michael Müller
Progress in Neurobiology, 2006, Volume 79, Number 3, Page 136
Yookeum Choi, Seul-Ki Kim, In-Young Choi, Chung Ju, Kung-Woo Nam, Sunyoung Hwang, Byung-Woo Kim, Min Ji Yoon, Moo-Ho Won, Yong-Ki Park, and Won-Ki Kim
Journal of Pharmacy and Pharmacology, 2011, Volume 63, Number 5, Page 695
Young-Jung Lee, Yoot Mo Lee, Chong-Kil Lee, Jae Kyung Jung, Sang Bae Han, and Jin Tae Hong
Pharmacology & Therapeutics, 2011, Volume 130, Number 2, Page 157
Sanju Dhawan, Rishi Kapil, and Bhupinder Singh
Journal of Pharmacy and Pharmacology, 2011, Volume 63, Number 3, Page 342
Anton P Porsteinsson and Kelly M Cosman
Aging Health, 2006, Volume 2, Number 6, Page 891
Yassine Chtourou, Hamadi Fetoui, Mediha Sefi, Khaled Trabelsi, Mohamed Barkallah, Tahia Boudawara, Héla Kallel, and Najiba Zeghal
BioMetals, 2010, Volume 23, Number 6, Page 985
Cláudia Funchal, Carlos Augusto Souza Carvalho, Tanise Gemelli, Andressa S. Centeno, Robson Brum Guerra, Mirian Salvador, Caroline Dani, Adriana Coitinho, and Rosane Gomez
Cellular and Molecular Neurobiology, 2010, Volume 30, Number 7, Page 1135
Carolina G. Fernandes, Guilhian Leipnitz, Bianca Seminotti, Alexandre U. Amaral, Ângela Zanatta, Carmen R. Vargas, Carlos S. Dutra Filho, and Moacir Wajner
Cellular and Molecular Neurobiology, 2010, Volume 30, Number 2, Page 317
Shu Yu, Yuntian Shen, Jie Liu, and Fei Ding
Journal of Molecular Neuroscience, 2010, Volume 40, Number 3, Page 321
Patrícia Fernanda Schuck, Estela Natacha Brandt Busanello, Alana Pimentel Moura, Anelise Miotti Tonin, Mateus Grings, Luciana Ritter, Carmen Regla Vargas, Gustavo da Costa Ferreira, and Moacir Wajner
Neurochemical Research, 2010, Volume 35, Number 2, Page 298
Zheng Feng and Jun-tian Zhang
Journal of Pineal Research, 2004, Volume 37, Number 4, Page 257
Phuong Thien Thuong, Yuba Raj Pokharel, Moo Yeol Lee, Sang Kyum Kim, KiHwan Bae, Nguyen Duy Su, Won Keun Oh, and Keon Wook Kang
Biological & Pharmaceutical Bulletin, 2009, Volume 32, Number 9, Page 1527
Annals of the New York Academy of Sciences, 2004, Volume 1012, Number 1, Page 342
Parvana Hajieva, Justyna B. Mocko, Bernd Moosmann, and Christian Behl
Journal of Neurochemistry, 2009, Volume 110, Number 1, Page 118
Dimitra Benaki, Konstantina Stathopoulou, Leondios Leondiadis, Nikolaos Ferderigos, Maria Pelecanou, and Emmanuel Mikros
Journal of Peptide Science, 2009, Volume 15, Number 6, Page 435
P. Mecocci, E. Mariani, V. Cornacchiola, and M.C. Polidori
Neurological Research, 2004, Volume 26, Number 5, Page 598
Guilhian Leipnitz, Alexandre F. Solano, Bianca Seminotti, Alexandre U. Amaral, Carolina G. Fernandes, Ana Paula Beskow, Carlos S. Dutra Filho, and Moacir Wajner
Cellular and Molecular Neurobiology, 2009, Volume 29, Number 2, Page 253
M. Cristina Polidori, Domenico Praticó, Tiziana Ingegni, Elena Mariani, Liana Spazzafumo, Paola Del Sindaco, Roberta Cecchetti, Yuemang Yao, Stefano Ricci, Antonio Cherubini, Wilhelm Stahl, Helmut Sies, Umberto Senin, Patrizia Mecocci, and Avasas Study Group
BioFactors, 2005, Volume 24, Number 1-4, Page 265
Kelly M Cosman, Lisa L Boyle, and Anton P Porsteinsson
Expert Opinion on Pharmacotherapy, 2007, Volume 8, Number 2, Page 203
Birgit Fogal and Sandra J. Hewett
Journal of Neurochemistry, 2008, Volume 106, Number 1, Page 1
Luciane Rosa Feksa, Alexandra Latini, Virgínia Cielo Rech, Patrícia Bartels Feksa, Gustavo Duarte Waltereith Koch, Maria Fernanda Arevalo Amaral, Guilhian Leipnitz, Carlos Severo Dutra-Filho, Moacir Wajner, and Clóvis Milton Duval Wannmacher
Metabolic Brain Disease, 2008, Volume 23, Number 2, Page 221
Guilhian Leipnitz, Bianca Seminotti, Josué Haubrich, Manuela B. Dalcin, Karina B. Dalcin, Alexandre Solano, Giorgia de Bortoli, Rafael B. Rosa, Alexandre U. Amaral, Carlos S. Dutra-Filho, Alexandra Latini, and Moacir Wajner
Journal of Neuroscience Research, 2008, Volume 86, Number 3, Page 683
In Koo Hwang, Ki-Yeon Yoo, Dae Won Kim, Jung Hoon Choi, In Se Lee, and Moo Ho Won
Neurochemical Research, 2007, Volume 32, Number 9, Page 1530
M. I. Panayiotidis, C. D. Bortner, and J. A. Cidlowski
Acta Physiologica, 2006, Volume 187, Number 1-2, Page 205
Ben S. Rayner, T. T. Hong Duong, Simon J. Myers, and Paul K. Witting
Journal of Neurochemistry, 2006, Volume 97, Number 1, Page 211
Claudia Eder
Journal of Neuroscience Research, 2005, Volume 81, Number 3, Page 314
Andrea Heyer, Martin Hasselblatt, Nicolas von Ahsen, Heinz Häfner, Anna-Leena Sirén, and Hannelore Ehrenreich
Journal of Cerebral Blood Flow & Metabolism, 2005, Volume 25, Number 4, Page 427
Emi Tsukamoto, Yuichi Hashimoto, Kohsuke Kanekura, Takako Niikura, Sadakazu Aiso, and Ikuo Nishimoto
Journal of Neuroscience Research, 2003, Volume 73, Number 5, Page 627

Comments (0)

Please log in or register to comment.