Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred


SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4315
See all formats and pricing

 


 
 

Select Volume and Issue
Loading journal volume and issue information...

Congopain from Trypanosoma congolense: Drug Target and Vaccine Candidate

Gilles Lalmanach / Alain Boulangé / Carole Serveau / Fabien Lecaille / Julio Scharfstein / Francis Gauthier / Edith Authié

Citation Information: Biological Chemistry. Volume 383, Issue 5, Pages 739–749, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2002.077, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Trypanosomes are the etiological agents of human sleeping sickness and livestock trypanosomosis (nagana), which are major diseases in Africa. Their cysteine proteases (CPs), which are members of the papain family, are expressed during the infective stages of the parasites life cycle. They are suspected to act as pathogenic factors in the mammalian host, where they also trigger prominent immune responses. Trypanosoma congolense, a major pathogenic species in livestock, possesses at least two families of closely related CPs, named CP1 and CP2. Congopain, a CP2-type of enzyme, shares structural and functional resemblances with cruzipain from T. cruzi and with mammalian cathepsin L. Like CPs from other Trypanosomatids, congopain might be an attractive target for trypanocidal drugs. Here we summarise the current knowledge in the two main areas of research on congopain: first, the biochemical properties of congopain were characterised and its substrate specificity was determined, as a first step towards drug design; second, the possibility was being explored that inhibition of congopain by hostspecific antibodies may mitigate the pathology associated with trypanosome infection.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Céline Perdereau, Emmanuel Godat, Marie-Christine Maurel, Eric Hazouard, Elisabeth Diot, and Gilles Lalmanach
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2006, Volume 1762, Number 3, Page 351
[2]
Roberta Ettari, Andrea Pinto, Lucia Tamborini, Ilenia C. Angelo, Silvana Grasso, Maria Zappalà, Natale Capodicasa, Laura Yzeiraj, Esther Gruber, Makoah N. Aminake, Gabriele Pradel, Tanja Schirmeister, Carlo De Micheli, and Paola Conti
ChemMedChem, 2014, Page n/a
[3]
Adriana C. Rodrigues, Paola A. Ortiz, André G. Costa-Martins, Luis Neves, Herakles A. Garcia, João M.P. Alves, Erney P. Camargo, Silvia C. Alfieri, Wendy Gibson, and Marta M.G. Teixeira
Infection, Genetics and Evolution, 2014, Volume 23, Page 20
[4]
Davita Pillay, Alain F.V. Boulangé, Virginie Coustou, Théo Baltz, and Theresa H.T. Coetzer
Experimental Parasitology, 2013, Volume 135, Number 4, Page 675
[5]
Roberta Ettari, Lucia Tamborini, Ilenia C. Angelo, Nicola Micale, Andrea Pinto, Carlo De Micheli, and Paola Conti
Journal of Medicinal Chemistry, 2013, Volume 56, Number 14, Page 5637
[6]
Hitoshi Aoki, Md Nazmul Ahsan, and Shugo Watabe
Protein Expression and Purification, 2003, Volume 31, Number 2, Page 213
[7]
Davita Pillay, Alain F. Boulangé, and Theresa H.T. Coetzer
Protein Expression and Purification, 2010, Volume 74, Number 2, Page 264
[8]
Alane P. Cortez, Adriana C. Rodrigues, Herakles A. Garcia, Luis Neves, Jael S. Batista, Zacharia Bengaly, Fernando Paiva, and Marta M.G. Teixeira
Molecular and Cellular Probes, 2009, Volume 23, Number 1, Page 44
[9]
P.A. Ortiz, F. Maia da Silva, A.P. Cortez, L. Lima, M. Campaner, E.M.F. Pral, S.C. Alfieri, and M.M.G. Teixeira
Acta Tropica, 2009, Volume 112, Number 3, Page 249
[10]
Adriana C. Rodrigues, Herakles A. Garcia, Paola A. Ortiz, Alane P. Cortez, Franjo Martinkovic, Fernando Paiva, Jael S. Batista, Antonio H. Minervino, Marta Campaner, Elizabeth M. Pral, Silvia C. Alfieri, and Marta M.G. Teixeira
Parasitology International, 2010, Volume 59, Number 3, Page 318
[11]
Jared R. Helm, Christiane Hertz-Fowler, Martin Aslett, Matthew Berriman, Mandy Sanders, Michael A. Quail, Marcelo B. Soares, Maria F. Bonaldo, Tatsuya Sakurai, Noboru Inoue, and John E. Donelson
Molecular and Biochemical Parasitology, 2009, Volume 168, Number 1, Page 34
[12]
Pascal Grébaut, Paul Chuchana, Jean-Paul Brizard, Edith Demettre, Martial Seveno, Géraldine Bossard, Patrick Jouin, Philippe Vincendeau, Zakaria Bengaly, Alain Boulangé, Gérard Cuny, and Philippe Holzmuller
International Journal for Parasitology, 2009, Volume 39, Number 10, Page 1137
[13]
Aleksandra Ruszczyk, Maria Forlenza, Huub F.J. Savelkoul, and Geert F. Wiegertjes
Fish & Shellfish Immunology, 2008, Volume 24, Number 2, Page 205
[14]
Aleksandra Ruszczyk, Maria Forlenza, Maaike Joerink, Carla M.S. Ribeiro, Patrycja Jurecka, and Geert F. Wiegertjes
Developmental & Comparative Immunology, 2008, Volume 32, Number 11, Page 1348
[15]
Alain F. Boulangé, Samoel A. Khamadi, Davita Pillay, Theresa H.T. Coetzer, and Edith Authié
Protein Expression and Purification, 2011, Volume 75, Number 1, Page 95
[16]
C. Serveau, A. Boulangé, F. Lecaille, F. Gauthier, E. Authié, and G. Lalmanach
Biological Chemistry, 2003, Volume 384, Number 6
[17]
Philippe Holzmuller, Pascal Grébaut, Gérard Cuny, and David Georges Biron
Expert Review of Proteomics, 2010, Volume 7, Number 1, Page 113
[18]
Stefan Magez and Magdalena Radwanska
Future Microbiology, 2009, Volume 4, Number 8, Page 1075
[19]
STEFAN MAGEZ, GUY CALJON, THAO TRAN, BENOÎT STIJLEMANS, and MAGDALENA RADWANSKA
Parasitology, 2010, Volume 137, Number 14, Page 2017
[20]
Hiroshi Kitani, Jan Naessens, Masanori Kubo, Yoshio Nakamura, Fuad Iraqi, John Gibson, and Minoru Yamakawa
Parasitology Research, 2009, Volume 105, Number 1, Page 217
[21]
Laura Elizabeth Joan Huson, Edith Authié, Alain François Boulangé, James Phillip Dean Goldring, and Theresa Helen Taillefer Coetzer
Veterinary Research, 2009, Page 52
[22]
M. CHENIK, S. LAKHAL, N. BEN KHALEF, L. ZRIBI, H. LOUZIR, and K. DELLAGI
Parasitology, 2006, Volume 132, Number 04, Page 493

Comments (0)

Please log in or register to comment.