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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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The Role of Dipeptidyl Peptidase IV (DP IV) Enzymatic Activity in T Cell Activation and Autoimmunity

D. Reinhold / T. Kähne / A. Steinbrecher / S. Wrenger / K. Neubert / S. Ansorge / S. Brocke

Citation Information: Biological Chemistry. Volume 383, Issue 7-8, Pages 1133–1138, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2002.123, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Activated T lymphocytes express high levels of dipeptidyl peptidase IV (DP IV)/CD26. Recent studies support the notion that DP IV may play an important role in the regulation of differentiation and growth of T lymphocytes. This article gives a short overview on DP IV/CD26 expression and effects on immune cells in vitro and in vivo. A major focus of this review are clinical aspects of the function of CD26 on hematopoietic cells and the potential usage of synthetic DP IV inhibitors as therapeutics in inflammatory disorders.

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