Jump to ContentJump to Main Navigation

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR increased in 2014: 3.268
Rank 106 out of 289 in category Biochemistry & Molecular Biology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

VolumeIssuePage

Issues

Biochemical Features, Molecular Biology and Clinical Relevance of the Human 15-Domain Serine Proteinase Inhibitor LEKTI

M. Walden / P. Kreutzmann / K. Drögemüller / H. John / W.-G. Forssmann / H.-J. Mägert

Citation Information: Biological Chemistry. Volume 383, Issue 7-8, Pages 1139–1141, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2002.124, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Based on the isolation of a 55 amino acid peptide from human hemofiltrate, we cloned the cDNA for a novel human 15-domain serine proteinase inhibitor termed LEKTI. A trypsininhibiting activity was demonstrated for three different domains. High levels of expression of the corresponding gene were detected in oral mucosa, followed by the tonsils, parathyroid glands, thymus, and trachea. Hovnanian and coworkers recently found that certain mutations within the LEKTI gene are linked to the severe congenital disease Netherton syndrome and atopic manifestations (including asthma). Thus, a future therapeutic use of LEKTI is conceivable.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Arumugam Jayakumar, Ya’an Kang, Ying Henderson, Kenji Mitsudo, Xiaoling Liu, Katrina Briggs, Mary Wang, Mitchell J. Frederick, Adel K. El-Naggar, Zsuzsa Bebök, and Gary L. Clayman
Archives of Biochemistry and Biophysics, 2005, Volume 435, Number 1, Page 89
[2]
David E. Metzger, Mildred T. Stahlman, and John M. Shannon
Developmental Biology, 2008, Volume 320, Number 1, Page 149
[3]
Matthias Schmuth, Robert Gruber, Peter M. Elias, and Mary L. Williams
Advances in Dermatology, 2007, Volume 23, Page 231
[4]
Daniela Roedl, Vinzenz Oji, Jeroen T.M. Buters, Heidrun Behrendt, and Markus Braun-Falco
Journal of Dermatological Science, 2011, Volume 61, Number 3, Page 194
[5]
T. Roelandt, B. Thys, C. Heughebaert, A. De Vroede, K. De Paepe, D. Roseeuw, B. Rombaut, and J.-P. Hachem
International Journal of Cosmetic Science, 2009, Volume 31, Number 4, Page 247
[6]
Jean-Pierre Hachem, Fredrik Wagberg, Matthias Schmuth, Debra Crumrine, Willy Lissens, Arumugam Jayakumar, Evi Houben, Theodora M Mauro, Göran Leonardsson, Maria Brattsand, Torbjorn Egelrud, Diane Roseeuw, Gary L Clayman, Kenneth R Feingold, Mary L Williams, and Peter M Elias
Journal of Investigative Dermatology, 2006, Volume 126, Number 7, Page 1609
[7]
T. Egelrud, M. Brattsand, P. Kreutzmann, M. Walden, K. Vitzithum, U.C. Marx, W.G. Forssmann, and H.J. Magert
British Journal of Dermatology, 2005, Volume 153, Number 6, Page 1200

Comments (0)

Please log in or register to comment.