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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

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Identification of an Allergen Related to Phl p 4, a Major Timothy Grass Pollen Allergen, in Pollens, Vegetables, and Fruits by Immunogold Electron Microscopy

M. Grote / S. Stumvoll / R. Reichelt / J. Lidholm / R. Valenta

Citation Information: Biological Chemistry. Volume 383, Issue 9, Pages 1441–1445, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2002.163, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Group 4 grass pollen allergens represent 60 kDa glycoproteins recognized by 70% of patients sensitive to these pollens. An antiserum against purified Phl p 4 from timothy grass pollen was used to investigate various pollens, fruits, and vegetables for Phl p 4-related allergens by immunogold electron microscopy. In timothy grass, mugwort, and birch pollens, allergens were located in the wall, and in timothy grass and birch pollens additionally in the cytoplasm. In peanut, apple, celery root, and carrot root, only cytoplasmic areas were labeled. Group 4-related allergens thus occur in pollens of unrelated plants and in plant food and may therefore contribute to crossreactivities in patients allergic to various pollens and plant food.

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