Jump to ContentJump to Main Navigation

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR increased in 2014: 3.268
Rank 106 out of 289 in category Biochemistry & Molecular Biology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

VolumeIssuePage

Issues

Cysteine cathepsins in human cancer

Christopher Jedeszko1 / Bonnie F. Sloane2

1.

2.

Corresponding author e-mail:

Citation Information: Biological Chemistry. Volume 385, Issue 11, Pages 1017–1027, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2004.132, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Proteases play causal roles in the malignant progression of human tumors. This review centers on the roles in this process of cysteine cathepsins, i.e., peptidases belonging to the papain family (C1) of the CA clan of cysteine proteases. Cysteine cathepsins, most likely along with matrix metalloproteases (MMPs) and serine proteases, degrade the extracellular matrix, thereby facilitating growth and invasion into surrounding tissue and vasculature. Studies on tumor tissues and cell lines have shown changes in expression, activity and distribution of cysteine cathepsins in numerous human cancers. Molecular, immunologic and pharmacological strategies to modulate expression and activity of cysteine cathepsins have provided evidence for a causal role for these enzymes in tumor progression and invasion. Clinically, the levels, activities and localization of cysteine cathepsins and their endogenous inhibitors have been shown to be of diagnostic and prognostic value. Understanding the roles that cysteine proteases play in cancer could lead to the development of more efficacious therapies.

Keywords: breast carcinoma; cathepsin B; colorectal carcinoma; cystatins; cysteine cathepsins; glioblastoma; melanoma; prostate carcinoma

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[2]
Ilaria Giusti, Sandra D’Ascenzo, Danilo Millimaggi, Giulia Taraboletti, Gaspare Carta, Nicola Franceschini, Antonio Pavan, and Vincenza Dolo
Neoplasia, 2008, Volume 10, Number 5, Page 481
[3]
Qingqing Zhang, Meiling Han, Wenjuan Wang, Yunzhen Song, Gang Chen, Zhong Wang, and Zhongqin Liang
Oncology Reports, 2015
[4]
Anestakis Doxakis, Argyraki Maria, Petanidis Savvas, and Iakovidou-Kritsi Zafiroula
Journal of Cancer Therapy, 2013, Volume 04, Number 06, Page 1
[5]
Sharareh Siamakpour-Reihani, Kouros Owzar, Chen Jiang, Peter M. Scarbrough, Oana I. Craciunescu, Janet K. Horton, Holly K. Dressman, Kimberly L. Blackwell, and Mark W. Dewhirst
International Journal of Hyperthermia, 2015, Volume 31, Number 4, Page 386
[6]
S J Salpeter, Y Pozniak, E Merquiol, Y Ben-Nun, T Geiger, and G Blum
Oncogene, 2015
[7]
Larissa P. Coppini, Bruna Visniauskas, Elaine F. Costa, Milton N. Filho, Eduardo B. Rodrigues, Jair R. Chagas, Michel E. Farah, Nilana M.T. Barros, and Adriana K. Carmona
Experimental Eye Research, 2015, Volume 134, Page 39
[8]
Neng Yang, Pan Wang, Wen-juan Wang, Yun-zhen Song, and Zhong-qin Liang
Acta Pharmacologica Sinica, 2015, Volume 36, Number 3, Page 400
[10]
Patricia E. Edem, Shannon Czorny, and John F. Valliant
Journal of Medicinal Chemistry, 2014, Volume 57, Number 22, Page 9564
[11]
Ramiro Vázquez, Lucile Astorgues-Xerri, Mohamed Bekradda, Julie Gormley, Richard Buick, Paul Kerr, Esteban Cvitkovic, Eric Raymond, Maurizio D'Incalci, Roberta Frapolli, and María E. Riveiro
Biochimie, 2015, Volume 108, Page 101
[12]
Hao-Wei Wang and Johanna A. Joyce
Cell Cycle, 2010, Volume 9, Number 24, Page 4824
[13]
Mohammad Haris, Anup Singh, Imran Mohammed, Ranjit Ittyerah, Kavindra Nath, Ravi Prakash Reddy Nanga, Catherine Debrosse, Feliks Kogan, Kejia Cai, Harish Poptani, Damodar Reddy, Hari Hariharan, and Ravinder Reddy
Scientific Reports, 2014, Volume 4
[14]
Jessica D. Knoll and Claudia Turro
Coordination Chemistry Reviews, 2015, Volume 282-283, Page 110
[15]
Aditi Jhaveri, Pranali Deshpande, and Vladimir Torchilin
Journal of Controlled Release, 2014, Volume 190, Page 352
[17]
Ditte Brix, Knut Clemmensen, and Tuula Kallunki
Cells, 2014, Volume 3, Number 1, Page 53
[18]
Neha Aggarwal and Bonnie F. Sloane
PROTEOMICS - Clinical Applications, 2014, Volume 8, Number 5-6, Page 427
[19]
V. I. Chorna and O. L. Lyanna
Biopolymers and Cell, 2011, Volume 27, Number 3, Page 181
[20]
Pengcheng Zhang, Lye Lin Lock, Andrew G. Cheetham, and Honggang Cui
Molecular Pharmaceutics, 2014, Volume 11, Number 3, Page 964
[22]
Tatiana A. Semashko, Elena A. Vorotnikova, Valeriya F. Sharikova, Konstantin S. Vinokurov, Yulia A. Smirnova, Yakov E. Dunaevsky, Mikhail A. Belozersky, Brenda Oppert, Elena N. Elpidina, and Irina Y. Filippova
Analytical Biochemistry, 2014, Volume 449, Page 179
[23]
Nobuhide Ueki, Siyeon Lee, Nicole S. Sampson, and Michael J. Hayman
Nature Communications, 2013, Volume 4
[24]
F Bengsch, A Buck, S C Günther, J R Seiz, M Tacke, D Pfeifer, D von Elverfeldt, L Sevenich, L E Hillebrand, U Kern, M Sameni, C Peters, B F Sloane, and T Reinheckel
Oncogene, 2014, Volume 33, Number 36, Page 4474
[25]
Chi-Chih Kang, Wei-Chun Huang, Chiung-Wen Kouh, Zi-Fu Wang, Chih-Chien Cho, Cheng-Chung Chang, Chiung-Lin Wang, Ta-Chau Chang, Joachim Seemann, and Lily Jun-shen Huang
Integrative Biology, 2013, Volume 5, Number 10, Page 1217
[26]
M Butinar, M T Prebanda, J Rajković, B Jerič, V Stoka, C Peters, T Reinheckel, A Krüger, V Turk, B Turk, and O Vasiljeva
Oncogene, 2014, Volume 33, Number 26, Page 3392
[27]
Lye Lin Lock, Andrew G. Cheetham, Pengcheng Zhang, and Honggang Cui
ACS Nano, 2013, Volume 7, Number 6, Page 4924
[28]
Dibyendu Dana, Anibal R. Davalos, Shatarupa De, Pratikkumar Rathod, Ranjith K. Gamage, Juliana Huestis, Nisar Afzal, Yuriy Zavlanov, Suneeta S. Paroly, Susan A. Rotenberg, Gopal Subramaniam, Kevin J. Mark, Emmanuel J. Chang, and Sanjai Kumar
Bioorganic & Medicinal Chemistry, 2013, Volume 21, Number 11, Page 2975
[29]
D. A. Grotsky, I. Gonzalez-Suarez, A. Novell, M. A. Neumann, S. C. Yaddanapudi, M. Croke, M. Martinez-Alonso, A. B. Redwood, S. Ortega-Martinez, Z. Feng, E. Lerma, T. Ramon y Cajal, J. Zhang, X. Matias-Guiu, A. Dusso, and S. Gonzalo
The Journal of Cell Biology, 2013, Volume 200, Number 2, Page 187
[30]
T Kallunki, O D Olsen, and M Jäättelä
Oncogene, 2013, Volume 32, Number 16, Page 1995
[31]
Benjamin L. Barthel, Daniel L. Rudnicki, Thomas Price Kirby, Sean M. Colvin, David J. Burkhart, and Tad H. Koch
Journal of Medicinal Chemistry, 2012, Volume 55, Number 14, Page 6595
[32]
Maciej Skrzypczak, Anette Springwald, Claus Lattrich, Julia Häring, Susanne Schüler, Olaf Ortmann, and Oliver Treeck
Cancer Investigation, 2012, Volume 30, Number 5, Page 398
[33]
Matthias Kotzsch, Juliane Farthmann, Axel Meye, Susanne Fuessel, Gustavo Baretton, Vivianne C.G. Tjan-Heijnen, Manfred Schmitt, Thomas Luther, Fred C.G.J. Sweep, Viktor Magdolen, and Paul N. Span
European Journal of Cancer, 2005, Volume 41, Number 17, Page 2760
[34]
Ronald D. Kinser and Patrick J. Dolph
Neurobiology of Disease, 2012, Volume 46, Number 3, Page 655
[35]
Susan A. Brooks, Hannah J. Lomax-Browne, Tracey M. Carter, Chloe E. Kinch, and Debbie M.S. Hall
Acta Histochemica, 2010, Volume 112, Number 1, Page 3
[36]
Hang Fai Kwok, Richard J Buick, Diana Kuehn, Julie A Gormley, Declan Doherty, Thomas J Jaquin, Angela McClurg, Claire Ward, Teresa Byrne, Jacob Jaworski, Ka Lai Leung, Philip Snoddy, Christine McAnally, Roberta E Burden, Breena Gray, Jenny Lowry, Isabelle Sermadiras, Natalia Gruszka, Nigel Courtenay-Luck, Adrien Kissenpfennig, Christopher J Scott, James A Johnston, and Shane A Olwill
Molecular Cancer, 2011, Volume 10, Number 1, Page 147
[37]
Vito Turk, Veronika Stoka, Olga Vasiljeva, Miha Renko, Tao Sun, Boris Turk, and Dušan Turk
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012, Volume 1824, Number 1, Page 68
[38]
J.M. Schmit, H.C. Pondenis, A.M. Barger, L.B. Borst, L.D. Garrett, J.M. Wypij, Z.L. Neumann, and T.M. Fan
Journal of Veterinary Internal Medicine, 2012, Volume 26, Number 1, Page 126
[39]
M. Ishida, F. Kojima, and H. Okabe
Journal of the European Academy of Dermatology and Venereology, 2013, Volume 27, Number 1, Page e128
[40]
Ishita Deb Majumdar, Arvind Devanabanda, Benjamin Fox, Jacob Schwartzman, Huan Cong, John A. Porco, and Horst C. Weber
Biochemical and Biophysical Research Communications, 2011, Volume 416, Number 3-4, Page 397
[41]
Asish K. Bhattacharya and Kalpeshkumar C. Rana
Bioorganic & Medicinal Chemistry, 2011, Volume 19, Number 23, Page 7129
[42]
Tomasz Respondek, Robert N. Garner, Mackenzie K. Herroon, Izabela Podgorski, Claudia Turro, and Jeremy J. Kodanko
Journal of the American Chemical Society, 2011, Volume 133, Number 43, Page 17164
[43]
T. Krucker and B. S. Sandanaraj
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2011, Volume 369, Number 1955, Page 4651
[44]
Mohd. Fahad Ullah and Mohammad Aatif
Cancer Treatment Reviews, 2009, Volume 35, Number 3, Page 193
[45]
Saša Kenig, María Beatriz Durán Alonso, Margareta M. Mueller, and Tamara T. Lah
Cancer Letters, 2010, Volume 289, Number 1, Page 53
[46]
Colja Cordes, Babett Bartling, Andreas Simm, Dany Afar, Christine Lautenschläger, Gesine Hansen, Rolf-Edgar Silber, Stefan Burdach, and Hans-Stefan Hofmann
Lung Cancer, 2009, Volume 64, Number 1, Page 79
[47]
Stefan Tholen, Martin L. Biniossek, Anna-Lena Geßler, Sebastian Müller, Juliane Weißer, Jayachandran N. Kizhakkedathu, Thomas Reinheckel, and Oliver Schilling
Biological Chemistry, 2011, Volume 392, Number 11
[49]
Benelita Tina Elie, Vasilena Gocheva, Tanaya Shree, Stacie A. Dalrymple, Leslie J. Holsinger, and Johanna A. Joyce
Biochimie, 2010, Volume 92, Number 11, Page 1618
[50]
Yongbao Zhu, Beth R. Cameron, Renee Mosi, Virginia Anastassov, Jennifer Cox, Ling Qin, Zefferino Santucci, Markus Metz, Renato T. Skerlj, and Simon P. Fricker
Journal of Inorganic Biochemistry, 2011, Volume 105, Number 5, Page 754
[51]
Jacqueline M. Lankelma, Daniëlle M. Voorend, Temo Barwari, Joris Koetsveld, Anne H. Van der Spek, Alexander P.N.A. De Porto, Geeske Van Rooijen, and Cornelis J.F. Van Noorden
Life Sciences, 2010, Volume 86, Number 7-8, Page 225
[52]
Marcelo Calderón, Ralph Graeser, Felix Kratz, and Rainer Haag
Bioorganic & Medicinal Chemistry Letters, 2009, Volume 19, Number 14, Page 3725
[53]
Ignacio Gonzalez-Suarez, Abena B Redwood, David A Grotsky, Martin A Neumann, Emily H-Y Cheng, Colin L Stewart, Adriana Dusso, and Susana Gonzalo
The EMBO Journal, 2011, Volume 30, Number 16, Page 3383
[54]
Adriana Miti Nakahata, Barbara Mayer, Christian Ries, Cláudia Alessandra Andrade de Paula, Marisa Karow, Peter Neth, Misako U. Sampaio, Marianne Jochum, and Maria Luiza V. Oliva
Biological Chemistry, 2011, Volume 392, Number 4
[55]
Simon P. Fricker, Renee M. Mosi, Beth R. Cameron, Ian Baird, Youngbao Zhu, Virginia Anastassov, Jennifer Cox, Patricia S. Doyle, Elizabeth Hansell, Gloria Lau, Jonathan Langille, Micki Olsen, Ling Qin, Renato Skerlj, Rebecca S.Y. Wong, Zefferino Santucci, and James H. McKerrow
Journal of Inorganic Biochemistry, 2008, Volume 102, Number 10, Page 1839
[57]
Fabien Lecaille, Dieter Brömme, and Gilles Lalmanach
Biochimie, 2008, Volume 90, Number 2, Page 208
[58]
D. J. Leeming, A. C. Bay-Jensen, E. Vassiliadis, M. R. Larsen, K. Henriksen, and M. A. Karsdal
Biomarkers, 2011, Volume 16, Number 3, Page 193
[59]
Richard H. Gomer, Wonhee Jang, and Derrick Brazill
Development, Growth & Differentiation, 2011, Volume 53, Number 4, Page 482
[60]
B Jelassi, A Chantôme, F Alcaraz-Pérez, A Baroja-Mazo, M L Cayuela, P Pelegrin, A Surprenant, and S Roger
Oncogene, 2011, Volume 30, Number 18, Page 2108
[61]
Matthew R. Pratt, Matthew D. Sekedat, Kyle P. Chiang, and Tom W. Muir
Chemistry & Biology, 2009, Volume 16, Number 9, Page 1001
[62]
Carmela Palermo and Johanna A. Joyce
Trends in Pharmacological Sciences, 2008, Volume 29, Number 1, Page 22
[63]
Claudine Tardy, Patrice Codogno, Hélène Autefage, Thierry Levade, and Nathalie Andrieu-Abadie
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2006, Volume 1765, Number 2, Page 101
[64]
Britto S Sandanaraj, Rainer Kneuer, and Nicolau Beckmann
Future Medicinal Chemistry, 2010, Volume 2, Number 3, Page 317
[65]
Nuzhat Motlekar, Scott L. Diamond, and Andrew D. Napper
ASSAY and Drug Development Technologies, 2008, Volume 6, Number 3, Page 395
[66]
Bonnie F. Sloane, Mansoureh Sameni, Izabela Podgorski, Dora Cavallo-Medved, and Kamiar Moin
Annual Review of Pharmacology and Toxicology, 2006, Volume 46, Number 1, Page 301
[67]
Andréia Gianotti, César A. Sommer, Adriana K. Carmona, and Flávio Henrique-Silva
Biological Chemistry, 2008, Volume 389, Number 4
[68]
Steven H. L. Verhelst, Martin D. Witte, Shirin Arastu-Kapur, Marko Fonovic, and Matthew Bogyo
ChemBioChem, 2006, Volume 7, Number 6, Page 943
[69]
X Yan, M Takahara, L Xie, Y Oda, T Nakahara, H Uchi, S Takeuchi, Y Tu, Y Moroi, and M Furue
Journal of the European Academy of Dermatology and Venereology, 2011, Volume 25, Number 3, Page 362
[70]
L Sevenich, F Werner, M Gajda, U Schurigt, C Sieber, S Müller, M Follo, C Peters, and T Reinheckel
Oncogene, 2011, Volume 30, Number 1, Page 54
[71]
Eleonore Fröhlich
Cellular and Molecular Life Sciences, 2010, Volume 67, Number 23, Page 3947
[72]
L. Sevenich, U. Schurigt, K. Sachse, M. Gajda, F. Werner, S. Muller, O. Vasiljeva, A. Schwinde, N. Klemm, J. Deussing, C. Peters, and T. Reinheckel
Proceedings of the National Academy of Sciences, 2010, Volume 107, Number 6, Page 2497
[73]
Simon P. Fricker
Metallomics, 2010, Volume 2, Number 6, Page 366
[74]
J Dennemärker, T Lohmüller, J Mayerle, M Tacke, M M Lerch, L M Coussens, C Peters, and T Reinheckel
Oncogene, 2010, Volume 29, Number 11, Page 1611
[75]
Marcelo Calderón, Mohiuddin Abdul Quadir, Sunil Kumar Sharma, and Rainer Haag
Advanced Materials, 2010, Volume 22, Number 2, Page 190
[76]
Jae-Young Sim, Mi-Ja Lee, and Keun-Hong Kee
The Korean Journal of Pathology, 2009, Volume 43, Number 5, Page 408
[77]
Sabina Rabzelj, Vito Turk, and Eva Žerovnik
Protein Science, 2005, Volume 14, Number 10, Page 2713
[78]
Nataša Obermajer, Bojan Doljak, and Janko Kos
Expert Opinion on Biological Therapy, 2006, Volume 6, Number 12, Page 1295
[79]
Norbert Schaschke, Irmgard Assfalg‐Machleidt, and Werner Machleidt
ChemBioChem, 2008, Volume 9, Number 11, Page 1721
[80]
O Vasiljeva, M Korovin, M Gajda, H Brodoefel, L Bojič, A Krüger, U Schurigt, L Sevenich, B Turk, C Peters, and T Reinheckel
Oncogene, 2008, Volume 27, Number 30, Page 4191
[81]
Garth Hamilton, Jeff D Colbert, Alexander W Schuettelkopf, and Colin Watts
The EMBO Journal, 2008, Volume 27, Number 3, Page 499
[82]
Galia Blum, Georges von Degenfeld, Milton J Merchant, Helen M Blau, and Matthew Bogyo
Nature Chemical Biology, 2007, Volume 3, Number 10, Page 668
[83]
André Warnecke, Iduna Fichtner, Gretel Saß, and Felix Kratz
Archiv der Pharmazie, 2007, Volume 340, Number 8, Page 389
[84]
Hanna C. Diehl, Kai Stühler, Susanne Klein-Scory, Martin W. Volmer, Anna Schöneck, Cornelia Bieling, Wolff Schmiegel, Helmut E. Meyer, and Irmgard Schwarte-Waldhoff
PROTEOMICS – Clinical Applications, 2007, Volume 1, Number 1, Page 47
[85]
Mona Mostafa Mohamed and Bonnie F. Sloane
Nature Reviews Cancer, 2006, Volume 6, Number 10, Page 764
[86]
Arjen R. de Boer, Ben Bruyneel, Johannes G. Krabbe, Henk Lingeman, Wilfried M. A. Niessen, and Hubertus Irth
Lab on a Chip, 2005, Volume 5, Number 11, Page 1286

Comments (0)

Please log in or register to comment.