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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year



Structural flexibility of small GTPases. Can it explain their functional versatility?

Ernst J.M. Helmreich1


Corresponding author ; Present address: Werner-von-siemens-Strasse 83, D-97076 Würzburg, Germany

Citation Information: Biological Chemistry. Volume 385, Issue 12, Pages 1121–1136, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2004.146, June 2005

Publication History

Published Online:


Multiple interactions with many different partners are responsible for the amazing functional versatility of proteins, especially those participating in cellular regulation. The structural properties that could facilitate multiple interactions are examined for small GTPases. The role of cellular constraints, compartmentation and scaffolds on protein-protein interactions is considered.

Keywords: cellular constraints; coupling versatility; flexible proteins; GTPase structure; small GTPases

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