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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer

Konstantina Mathioudaki1 / Andreas Scorilas2 / Alexandra Papadokostopoulou3 / Dimitrios Xynopoulos4 / Niki Arnogianaki5 / Niki Agnanti6 / Maroulio Talieri7








Citation Information: Biological Chemistry. Volume 385, Issue 9, Pages 779–783, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2004.101, June 2005

Publication History

February 17, 2004
June 29, 2004
Published Online:


Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients. In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RT-PCR. Two transcripts, BCL2L12 and BCL2L12-A, were overexpressed in the cancer tissues as compared to their paired normal mucosa. An association was found between BCL2L12-A transcript expression and nodal status, as well as Dukes’ stage. The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression.

Keywords: apoptosis; BCL2L12; colon cancer

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