Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner : Biological Chemistry

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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner

Helen E. Townley1 / Kerrie McDonald2 / Gareth I. Jenkins3 / Marc R. Knight4 / Christopher J. Leaver5






These authors contributed equally to this work; Corresponding author

Citation Information: Biological Chemistry. Volume 386, Issue 2, Pages 161–166, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2005.020, June 2005

Publication History

October 18, 2004
December 17, 2004
Published Online:


While the role of C2-ceramide in the induction of programmed cell death (PCD) in animal systems has been well documented, little is known of its role in plant cells. Here we show that C2-ceramide induces PCD in Arabidopsis suspension cultures, which is preceded by the generation of a calcium transient and an increase in reactive oxygen species (ROS). Inhibition of the calcium transient prevented cell death, whereas inhibition of ROS had no effect on cell survival. These observations suggest that calcium signalling plays a role in ceramide-induced PCD but is independent of the generation of ROS.

Keywords: apoptosis; calcium signalling; reactive oxygen species

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