Jump to ContentJump to Main Navigation

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR increased in 2014: 3.268
Rank 106 out of 289 in category Biochemistry & Molecular Biology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.596
Source Normalized Impact per Paper (SNIP) 2014: 0.845
Impact per Publication (IPP) 2014: 2.992



Aspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways

Claus Jacob1 / Iona Knight2 / Paul G. Winyard3




Corresponding author

Citation Information: Biological Chemistry. Volume 387, Issue 10/11, Pages 1385–1397, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2006.174, November 2006

Publication History

Published Online:


The last decade has witnessed an increased interest in cysteine modifications such as sulfenic and sulfinic acids, thiyl radicals, sulfenyl-amides and thiosulfinates, which come together to enable redox sensing, activation, catalysis, switching and cellular signalling. While glutathionylation, sulfenyl-amide formation and disulfide activation are examples of relatively simple redox responses, the sulfinic acid switch in peroxiredoxin enzymes is part of a complex signalling system that involves sulfenic and sulfinic acids and interacts with kinases and sulfiredoxin. Although the in vivo evaluation of sulfur species is still complicated by a lack of appropriate analytical techniques, research into biological sulfur species has gained considerable momentum and promises further excitement in the future.

Keywords: oxidative stress; peroxiredoxin; sulfenic acid; sulfenyl amide; sulfinic acid; thiosulfinate

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Zhong Fang and Patricia C. Dos Santos
MicrobiologyOpen, 2015, Page n/a
Marie-Laure Kleme and Emile Levy
Antioxidants & Redox Signaling, 2015, Volume 22, Number 7, Page 614
Rahul Checker, Lokesh Gambhir, Deepak Sharma, Mukesh Kumar, and Santosh K. Sandur
Cancer Letters, 2015, Volume 357, Number 1, Page 265
Jie Wang, Kristeen A Pareja, Chris A Kaiser, and Carolyn S Sevier
eLife, 2014, Volume 3
M. Halloran, S. Parakh, and J. D. Atkin
International Journal of Cell Biology, 2013, Volume 2013, Page 1
Z. Papanyan and S. Markarian
Journal of Applied Spectroscopy, 2013, Volume 80, Number 5, Page 775
Rajat Chauhan, Mark S. Mashuta, and Craig A. Grapperhaus
Inorganic Chemistry Communications, 2013, Volume 37, Page 186
Diana I. Aparicio-Bautista, Julio I. Pérez-Carreón, Nora Gutiérrez-Nájera, Juan P. Reyes-Grajeda, Jaime Arellanes-Robledo, Verónica R. Vásquez-Garzón, Mónica N. Jiménez-García, and Saúl Villa-Treviño
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013, Volume 1834, Number 12, Page 2528
Uma M. Viswanathan, Torsten Burkholz, and Claus Jacob
Zeitschrift für Physikalische Chemie, 2013, Volume 227, Number 5, Page 691
Alberto Bindoli and Maria Pia Rigobello
Antioxidants & Redox Signaling, 2013, Volume 18, Number 13, Page 1557
Min-Sik Kim, Yann S. Dufour, Ji Sun Yoo, Yoo-Bok Cho, Joo-Hong Park, Gi-Baeg Nam, Hae Min Kim, Kang-Lok Lee, Timothy J. Donohue, and Jung-Hye Roe
Molecular Microbiology, 2012, Volume 85, Number 2, Page 326
Brenda E. Lopez, David A. Wink, and Jon M. Fukuto
Archives of Biochemistry and Biophysics, 2007, Volume 465, Number 2, Page 430
Hongqiao Zhang and Henry Jay Forman
Seminars in Cell & Developmental Biology, 2012, Volume 23, Number 7, Page 722
Françoise Montrichard, Fatima Alkhalfioui, Hiroyuki Yano, William H. Vensel, William J. Hurkman, and Bob B. Buchanan
Journal of Proteomics, 2009, Volume 72, Number 3, Page 452
Gabriele Siedenburg, Matthew R. Groves, and Darío Ortiz de Orué Lucana
Antioxidants & Redox Signaling, 2012, Volume 16, Number 7, Page 668
Elizabeth A. Sabens Liedhegner, Xing-Huang Gao, and John J. Mieyal
Antioxidants & Redox Signaling, 2012, Volume 16, Number 6, Page 543
Thomas D. Lockwood
Experimental Parasitology, 2008, Volume 118, Number 4, Page 604
Tapan Kanti Paine, Debobrata Sheet, Thomas Weyhermüller, and Phalguni Chaudhuri
European Journal of Inorganic Chemistry, 2011, Volume 2011, Number 34, Page 5250
Daniela Braconi, Giulia Bernardini, and Annalisa Santucci
Journal of Proteomics, 2011, Volume 74, Number 11, Page 2324
Darío Ortiz de Orué Lucana, Ina Wedderhoff, and Matthew R. Groves
Journal of Signal Transduction, 2012, Volume 2012, Page 1
Dirk Wesenberg, Gerd-Joachim Krauss, and Dirk Schaumlöffel
International Journal of Mass Spectrometry, 2011, Volume 307, Number 1-3, Page 46
Matty Knight, Nithya Raghavan, Cheri Goodall, Carolyn Cousin, Wannaporn Ittiprasert, Ahmed Sayed, Andre Miller, David L. Williams, and Christopher J. Bayne
Molecular and Biochemical Parasitology, 2009, Volume 167, Number 1, Page 20
E. N. Budanova and M. F. Bystrova
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2011, Volume 5, Number 3, Page 219
Enrique Herrero, Joaquim Ros, Gemma Bellí, and Elisa Cabiscol
Biochimica et Biophysica Acta (BBA) - General Subjects, 2008, Volume 1780, Number 11, Page 1217
Noriyuki Nagahara
Journal of Amino Acids, 2011, Volume 2011, Page 1
Karl-Josef Dietz
Antioxidants & Redox Signaling, 2011, Volume 15, Number 4, Page 1129
Thamayanthy Sriskandakumar, Holm Petzold, Pieter C. A. Bruijnincx, Abraha Habtemariam, Peter J. Sadler, and Pierre Kennepohl
Journal of the American Chemical Society, 2009, Volume 131, Number 37, Page 13355
Michael B. Reid
Free Radical Biology and Medicine, 2008, Volume 44, Number 2, Page 169
Isabella Dalle–Donne, Aldo Milzani, Nicoletta Gagliano, Roberto Colombo, Daniela Giustarini, and Ranieri Rossi
Antioxidants & Redox Signaling, 2008, Volume 10, Number 3, Page 445
William Remelli, Angelo Cereda, Jutta Papenbrock, Fabio Forlani, and Silvia Pagani
Biological Chemistry, 2010, Volume 391, Number 7
Claudia Cerella, Christiane Scherer, Silvia Cristofanon, Estelle Henry, Awais Anwar, Corinna Busch, Mathias Montenarh, Mario Dicato, Claus Jacob, and Marc Diederich
Apoptosis, 2009, Volume 14, Number 5, Page 641
Y. H. Seo and K. S. Carroll
Proceedings of the National Academy of Sciences, 2009, Volume 106, Number 38, Page 16163
C. Scherer, C. Jacob, M. Dicato, and M. Diederich
Phytochemistry Reviews, 2009, Volume 8, Number 2, Page 349
Xing-Huang Gao, Mariette Bedhomme, Daniel Veyel, Mirko Zaffagnini, and Stéphane D. Lemaire
Molecular Plant, 2009, Volume 2, Number 2, Page 218
Fabio Di Domenico, Giovanna Cenini, Rukhsana Sultana, Marzia Perluigi, Daniela Uberti, Maurizio Memo, and D. Allan Butterfield
Neurochemical Research, 2009, Volume 34, Number 4, Page 727
S. Rinalducci, L. Murgiano, and L. Zolla
Journal of Experimental Botany, 2008, Volume 59, Number 14, Page 3781
Claus Jacob and Awais Anwar
Physiologia Plantarum, 2008, Volume 133, Number 3, Page 469
Peter G Arthur, Miranda D Grounds, and Thea Shavlakadze
Current Opinion in Clinical Nutrition and Metabolic Care, 2008, Volume 11, Number 4, Page 408
Sumarin Soonsanga, Jin-Won Lee, and John D. Helmann
Molecular Microbiology, 2008, Volume 68, Number 4, Page 978
Miroslav Malešević, Günther Jahreis, Stephan Wawra, Gunter Fischer, and Christian Lücke
ChemBioChem, 2008, Volume 9, Number 1, Page 46
Chien-Wen Hung, Andreas Schlosser, Junhua Wei, and Wolf D. Lehmann
Analytical and Bioanalytical Chemistry, 2007, Volume 389, Number 4, Page 1003

Comments (0)

Please log in or register to comment.