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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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A comprehensive nomenclature for serine proteases with homology to tissue kallikreins

Åke Lundwall1 / Vimla Band2 / Michael Blaber3 / Judith A. Clements4 / Yves Courty5 / Eleftherios P. Diamandis6 / Hans Fritz7 / Hans Lilja8 / Johan Malm9 / Lois J. Maltais10 / A. Yvonne Olsson11 / Constantina Petraki12 / Andreas Scorilas13 / Georgia Sotiropoulou14 / Ulf-Håkan Stenman15 / Carsten Stephan16 / Maroulio Talieri17 / George M. Yousef18



















Corresponding author

Citation Information: Biological Chemistry. Volume 387, Issue 6, Pages 637–641, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2006.082, June 2006

Publication History

Published Online:


The human kallikrein locus on chromosome 19q13.3–13.4 contains kallikrein 1 – the tissue kallikrein – and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present nomenclature for these proteins is inadequate or insufficient. Here we present a new nomenclature in which proteins without proven kininogenase activity are denoted kallikrein-related peptidase. Names are also given to the unique rodent proteins that are closely related to kallikrein 1.

Keywords: cancer; evolution; hormone; inflammation; kininogen

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