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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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SCImago Journal Rank (SJR): 1.550
Source Normalized Impact per Paper (SNIP): 0.734

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Extracellular granzymes: current perspectives

Marguerite S. Buzza1 / Phillip I. Bird2

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Corresponding author

Citation Information: Biological Chemistry. Volume 387, Issue 7, Pages 827–837, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2006.106, July 2006

Publication History

Published Online:
2006-07-20

Abstract

Granzyme A (GrA) and granzyme B (GrB) play key roles in the induction of target cell death induced by cytotoxic lymphocytes. Whilst these roles have been extensively studied, it is becoming apparent that both granzymes also possess extracellular activities. Soluble granzymes are found extracellularly in normal plasma and are elevated in a number of diseases, ranging from viral and bacterial infections to autoimmune diseases. Here, we discuss the current knowledge of extracellular granzyme substrates, inhibitors and functions; and the pathological consequences of extracellular granzymes in disease. In addition, we provide new evidence for the role of glycosaminoglycan-binding sites of granzymes in extracellular matrix remodeling.

Keywords: extracellular matrix remodeling; perforin-independent; soluble granzyme A; soluble granzyme B

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