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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred


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Protease research in the era of systems biology

Ulrich auf dem Keller1 / Alain Doucet2 / Christopher M. Overall3

1The UBC Centre for Blood Research, Department of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, BC, Canada

2The UBC Centre for Blood Research, Department of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, BC, Canada

3The UBC Centre for Blood Research, Department of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, BC, Canada

Corresponding author

Citation Information: Biological Chemistry. Volume 388, Issue 11, Pages 1159–1162, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: 10.1515/BC.2007.146, November 2007

Publication History

Published Online:
2007-11-02

Abstract

Proteases are specific modulators of signaling molecules and their underlying pathways in addition to their degradative roles. However, proteases do not act alone, but form cascades, circuits and networks that all dynamically interconnect to form the protease web, which defines the proteolytic potential of a cell or tissue in a defined condition. To describe the protease web and its net activity several novel high-throughput proteomic techniques, in the field termed degradomics, have been developed. Emerging systems biology methods to evaluate the expression, activity and substrate discovery of proteases are presented. Understanding the protease web and its perturbations in pathology will help to develop new therapeutics for the treatment of diseases, such as cancer, arthritis and chronic obstructive pulmonary diseases.

Keywords: degradomics; protease; protease web; proteomics; transcriptomics

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