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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year



FOXM1, a typical proliferation-associated transcription factor

Inken Wierstra1 / Jürgen Alves2

1Wißmannstr. 17, D-30173 Hannover, Germany

2Institute of Biophysical Chemistry, Medical School Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany

Corresponding author

Citation Information: Biological Chemistry. Volume 388, Issue 12, Pages 1257–1274, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: 10.1515/BC.2007.159, November 2007

Publication History

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FOXM1 is a typical proliferation-associated transcription factor: it stimulates proliferation by promoting S-phase entry as well as M-phase entry and is involved in proper execution of mitosis. Accordingly, FOXM1 regulates genes that control G1/S-transition, S-phase progression, G2/M-transition and M-phase progression. Consistently, its expression and its activity are antagonistically regulated by many important proliferation and anti-proliferation signals. Furthermore, FOXM1 is implicated in tumorigenesis and contributes to both tumor initiation and progression. In addition to its function as a conventional transcription factor, FOXM1 transactivates the human c-myc P1 and P2 promoters directly via their TATA-boxes by a new transactivation mechanism, which it also employs for transactivation of the human c-fos, hsp70 and histone H2B/a promoters. This review summarizes the current knowledge on FOXM1, in particular its two different transactivation mechanisms, the regulation of its transcriptional activity by proliferation versus anti-proliferation signals and its function in normal cell cycle progression and tumorigenesis.

Keywords: cell cycle; cell proliferation; mitosis; S-phase; tissue regeneration; tumorigenesis

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