Editor-in-Chief: Brüne, Bernhard
Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred
SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609
Idiosyncratic cleavage and ligation activity of individual hammerhead ribozymes and core sequence variants thereof
1AG Molecular Interactions, Department of Genetics, University of Kassel, Heinrich-Plett-Str. 40, D-34132 Kassel, Germany
2AG Molecular Interactions, Department of Genetics, University of Kassel, Heinrich-Plett-Str. 40, D-34132 Kassel, Germany
Citation Information: Biological Chemistry. Volume 388, Issue 7, Pages 737–741, ISSN (Online) 14316730, ISSN (Print) 14374315, DOI: 10.1515/BC.2007.065, July 2007
- Published Online:
The hammerhead ribozyme is a small RNA endonuclease found in sub-viral plant pathogens, in transcripts from certain animal satellite DNAs and encoded at distinct loci of Arabidopsis thaliana. Kinetic analyses of tertiary stabilised ribozymes from peach latent mosaic viroid (PLMVd), Schistosoma mansoni and A. thaliana revealed a ten-fold difference in cleavage rates. Core nucleotide variations affected cleavage reactions least in the A. thaliana ribozyme, and most in the S. mansoni ribozyme. The reverse ligation reaction was catalysed efficiently by the PLMVd and A. thaliana ribozymes. The different behaviour of the individual hammerhead ribozymes is discussed in terms of structure and function.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.