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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred


SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

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1437-4315
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Potential biomarkers of ageing

Andreas Simm1 / Norbert Nass2 / Babett Bartling3 / Britt Hofmann4 / Rolf-Edgar Silber5 / Alexander Navarrete Santos6

1Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany

2Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany

3Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany

4Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany

5Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany

6Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany

Corresponding author

Citation Information: Biological Chemistry. Volume 389, Issue 3, Pages 257–265, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: 10.1515/BC.2008.034, March 2008

Publication History

Published Online:
2008-03-03

Abstract

Life span in individual humans is very heterogeneous. Thus, the ageing rate, measured as the decline of functional capacity and stress resistance, is different in every individual. There have been attempts made to analyse this individual age, the so-called biological age, in comparison to chronological age. Biomarkers of ageing should help to characterise this biological age and, as age is a major risk factor in many degenerative diseases, could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. Markers based on oxidative stress, protein glycation, inflammation, cellular senescence and hormonal deregulation are discussed.

Keywords: ageing; hormones; inflammation; oxidative stress; protein glycation

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