1Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
2Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
3Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
4Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
5Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
6Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
Citation Information: Biological Chemistry. Volume 389, Issue 3, Pages 257–265, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: 10.1515/BC.2008.034, March 2008
Abstract
Life span in individual humans is very heterogeneous. Thus, the ageing rate, measured as the decline of functional capacity and stress resistance, is different in every individual. There have been attempts made to analyse this individual age, the so-called biological age, in comparison to chronological age. Biomarkers of ageing should help to characterise this biological age and, as age is a major risk factor in many degenerative diseases, could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. Markers based on oxidative stress, protein glycation, inflammation, cellular senescence and hormonal deregulation are discussed.
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