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Publication Date:
March 2008
ISSN:
1437-4315
DOI:
10.1515/BC.2008.053

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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Ludwig, Stephan / Sies, Helmut / Stoffel, Markus / Turk, Boris / Wittinghofer, Alfred / Baumeister, Wolfgang / Bergeron, John / Bogyo, Matthew / Bürkle, Alexander / Cadenas, Enrique / Chiti, Fabrizio / Dikic, Ivan / Dobson, Christopher / Driessen, Arnold / Fritz, Hans / Gevaert, Kris / Hammann, Christian / Hartl, F. Ulrich / Häussinger, Dieter / Hiscott, John / Igarashi, Yasuyuki / Klotz, Lars-Oliver / Krüger, Achim / Magdolen, Viktor / Müschen, Markus / Narumiya, Shuh / Naumann, Michael / Pejler, Gunnar / Pfanner, Nikolaus / Pike, Robert / Potempa, Jan / Saftig, Paul / Sandhoff, Konrad / Schaffner, Walter / Sinning, Irmgard / Sommerhoff, Christian P.

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Novel strategies to identify biomarkers in tuberculosis

Marc Jacobsen1 / Jens Mattow2 / Dirk Repsilber3 / Stefan H.E. Kaufmann4

Present address: Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.
1Max Planck Institute for Infection Biology, Department of Immunology, D-10117 Berlin, Germany

2Max Planck Institute for Infection Biology, Department of Immunology, D-10117 Berlin, Germany

3Research Institute for the Biology of Farm Animals, Genetics and Biometry, D-18196 Dummerstorf, Germany

4Max Planck Institute for Infection Biology, Department of Immunology, D-10117 Berlin, Germany

Corresponding author

Citation Information: Biological Chemistry. Volume 389, Issue 5, Pages 487–495, ISSN (Online) 14374315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2008.053, March 2008

Publication History:
Published Online:
2008-03-27

Abstract

The more we learn about the immune response against tuberculosis (TB) and particularly about the features which distinguish protective immunity, disease susceptibility and pathology, the better we can define biomarkers which correlate with these different stages of infection. The most widely used biomarker in TB, which without a doubt is an important component of protective immunity, is IFNγ secreted by antigen-specific CD4 T-cells. However, the complexity of the immune response against TB makes it more than likely that additional biomarkers are required for a reliable correlate of protection. As a corollary, we assume that a set of biomarkers will be required, termed a biosignature.

Keywords: antigen; biosignature; metabolomics; proteomics; T-cells; transcriptomics

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