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Publication Date:
27 03 2008
ISSN:
1437-4315
DOI:
10.1515/BC.2008.063

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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

null Ludwig, Stephan / Sies, Helmut / Stoffel, Markus / Turk, Boris / Wittinghofer, Alfred / Baumeister, Wolfgang / Bergeron, John / Bogyo, Matthew / Bürkle, Alexander / Cadenas, Enrique / Chiti, Fabrizio / Dikic, Ivan / Dobson, Christopher / Driessen, Arnold / Fritz, Hans / Gevaert, Kris / Hammann, Christian / Hartl, F. Ulrich / Häussinger, Dieter / Hiscott, John / Igarashi, Yasuyuki / Klotz, Lars-Oliver / Krüger, Achim / Magdolen, Viktor / Müschen, Markus / Narumiya, Shuh / Naumann, Michael / Pejler, Gunnar / Pfanner, Nikolaus / Pike, Robert / Potempa, Jan / Saftig, Paul / Sandhoff, Konrad / Schaffner, Walter / Sinning, Irmgard / Sommerhoff, Christian P.

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Construction of an encapsulated ESAT-6-based anti-TB DNA vaccine and evaluation of its immunogenic properties

Nosareva, Olesya 1 / Nesterov, Andrey 2 / Boldyrev, Alexander 3 / Smirnova, Olga 4 / Tumanov, Yurii 5 / Kouzmitcheva, Galina 6 / Tatkov, Sergey 7

1 FSRI State Research Center of Virology and Biotechnology ‘VECTOR’, Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Novosibirsk Region, 630559 Koltsovo, Russia

2 FSRI State Research Center of Virology and Biotechnology ‘VECTOR’, Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Novosibirsk Region, 630559 Koltsovo, Russia

3 FSRI State Research Center of Virology and Biotechnology ‘VECTOR’, Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Novosibirsk Region, 630559 Koltsovo, Russia

4 FSRI State Research Center of Virology and Biotechnology ‘VECTOR’, Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Novosibirsk Region, 630559 Koltsovo, Russia

5 FSRI State Research Center of Virology and Biotechnology ‘VECTOR’, Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Novosibirsk Region, 630559 Koltsovo, Russia

6 FSRI State Research Center of Virology and Biotechnology ‘VECTOR’, Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Novosibirsk Region, 630559 Koltsovo, Russia

7 FSRI State Research Center of Virology and Biotechnology ‘VECTOR’, Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Novosibirsk Region, 630559 Koltsovo, Russia

Corresponding author

Citation Information: Biological Chemistry. Volume 389, Issue 5, Pages 579–583, ISSN (Online) 14374315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2008.063, March 2008

Publication History:

Received: 27/09/2007;
Accepted: 04/02/2008;
Published Online: 05/03/2012

Abstract

Experimental preparations based on a DNA vaccine encoding the ESAT-6 antigen of Mycobacterium tuberculosis have been obtained (KpONE6) and studied for immunogenic effects in the murine model. The core of the preparation contains DNA of the recombinant plasmid pONE6 encapsulated within a spermidine-polyglucin conjugate, thereby protecting the DNA vaccine from degradation. KpONE6 induces a proliferative T-cell immune response in mice upon intramuscular immunization.

Keywords: DNA vaccine; ESAT-6; Mycobacterium tuberculosis ; polysaccharide-spermidine matrix

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