Jump to ContentJump to Main Navigation

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR increased in 2014: 3.268
Rank 106 out of 289 in category Biochemistry & Molecular Biology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.596
Source Normalized Impact per Paper (SNIP) 2014: 0.845
Impact per Publication (IPP) 2014: 2.992



Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family

Marco Dieckmann1, 2 / Martin Frederik Dietrich1 / Joachim Herz1

1Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9046, USA

2Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, D-55099 Mainz, Germany

Corresponding author

Citation Information: Biological Chemistry. Volume 391, Issue 11, Pages 1341–1363, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/bc.2010.129, September 2010

Publication History

Published Online:


The evolutionarily ancient low-density lipoprotein (LDL) receptor gene family represents a class of widely expressed cell surface receptors. Since the dawn of the first primitive multicellular organisms, several structurally and functionally distinct families of lipoprotein receptors have evolved. In accordance with the now obsolete ‘one-gene-one-function’ hypothesis, these cell surface receptors were orginally perceived as mere transporters of lipoproteins, lipids, and nutrients or as scavenger receptors, which remove other kinds of macromolecules, such as proteases and protease inhibitors from the extracellular environment and the cell surface. This picture has since undergone a fundamental change. Experimental evidence has replaced the perception that these receptors serve merely as cargo transporters. Instead it is now clear that the transport of macromolecules is inseparably intertwined with the molecular machinery by which cells communicate with each other. Lipoprotein receptors are essentially sensors of the extracellular environment that participate in a wide range of physiological processes by physically interacting and coevolving with primary signal transducers as co-regulators. Furthermore, lipoprotein receptors modulate cellular trafficking and localization of the amyloid precursor protein (APP) and the β-amyloid peptide (Aβ), suggesting a role in the pathogenesis of Alzheimer's disease. Moreover, compelling evidence shows that LDL receptor family members are involved in tumor development and progression.

Keywords: Alzheimer; ApoE; atherosclerosis; brain development; LRP; neuromuscular junction

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Melinde Wijers, Jan A. Kuivenhoven, and Bart van de Sluis
Current Opinion in Lipidology, 2015, Volume 26, Number 2, Page 82
Rik van der Kant and Lawrence S.B. Goldstein
Developmental Cell, 2015, Volume 32, Number 4, Page 502
C. R. Wasser, I. Masiulis, M. S. Durakoglugil, C. Lane-Donovan, X. Xian, U. Beffert, A. Agarwala, R. E. Hammer, and J. Herz
Science Signaling, 2014, Volume 7, Number 353, Page ra113
Huang Huang, William Cruz, Juan Chen, and Gang Zheng
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2015, Volume 7, Number 3, Page 298
Evan Dorey, Nina Chang, Qing Yan Liu, Ze Yang, and Wandong Zhang
Neuroscience Bulletin, 2014, Volume 30, Number 2, Page 317
Christian B.F. Andersen and Søren K. Moestrup
Trends in Biochemical Sciences, 2014, Volume 39, Number 2, Page 82
Hong Y Choi, Yun Liu, Christian Tennert, Yoshie Sugiura, Andromachi Karakatsani, Stephan Kröger, Eric B Johnson, Robert E Hammer, Weichun Lin, and Joachim Herz
eLife, 2013, Volume 2
Ahmed A. Rehman, Haseeb Ahsan, and Fahim H. Khan
Journal of Cellular Physiology, 2013, Volume 228, Number 8, Page 1665
Danese M. Joiner, Jiyuan Ke, Zhendong Zhong, H. Eric Xu, and Bart O. Williams
Trends in Endocrinology & Metabolism, 2013, Volume 24, Number 1, Page 31
Abhay P. Sagare, Rashid Deane, and Berislav V. Zlokovic
Pharmacology & Therapeutics, 2012, Volume 136, Number 1, Page 94
D. R. Dries, G. Yu, and J. Herz
Proceedings of the National Academy of Sciences, 2012, Volume 109, Number 9, Page 3199
Lisa A. Lambert
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012, Volume 1820, Number 3, Page 244
Shuo Chen, Doryen Bubeck, Bryan T. MacDonald, Wen-Xue Liang, Jian-Hua Mao, Tomas Malinauskas, Oscar Llorca, A. Radu Aricescu, Christian Siebold, Xi He, and E. Yvonne Jones
Developmental Cell, 2011, Volume 21, Number 5, Page 848
Jennifer L. Jones, Youngki Park, Jiyoung Lee, Robert H. Lerman, and Maria Luz Fernandez
Nutrition Research, 2011, Volume 31, Number 9, Page 659
Hideki Hayashi
Biological & Pharmaceutical Bulletin, 2011, Volume 34, Number 4, Page 453

Comments (0)

Please log in or register to comment.