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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Physiology and pathophysiology of the RANKL/RANK system

Reiko Hanada1 / Toshikatsu Hanada1 / Josef M. Penninger1

1Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, A-1030 Vienna, Austria

Corresponding author

Citation Information: Biological Chemistry. Volume 391, Issue 12, Pages 1365–1370, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/bc.2010.149, November 2010

Publication History

Published Online:


The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.

Keywords: bone physiology; central nervous systems; fever; immunology; osteoporosis

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