Editor-in-Chief: Brüne, Bernhard
Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred
SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609
Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis
1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA
2Department of Chemistry, Yale University, New Haven, CT 06520-8114, USA
3Department of Medicine I, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany
4Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S. Ashland Ave., MBRB 1170, Chicago, IL 60607, USA
Citation Information: Biological Chemistry. Volume 391, Issue 7, Pages 771–776, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/bc.2010.078, May 2010
- Published Online:
Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) that converts phosphoseryl-tRNASec to selenocysteinyl-tRNASec. The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. Here we review the discovery of human SepSecS and the current understanding of the immunogenicity of SLA/LP in autoimmune hepatitis.
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