Jump to ContentJump to Main Navigation

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR increased in 2014: 3.268
Rank 106 out of 289 in category Biochemistry & Molecular Biology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.596
Source Normalized Impact per Paper (SNIP) 2014: 0.845
Impact per Publication (IPP) 2014: 2.992



Towards molecular systems biology of gene transcription and regulation

Patrick Cramer1

1Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig Maximilians University, Feodor-Lynen-Straße 25, D-81377 Munich, Germany

Citation Information: Biological Chemistry. Volume 391, Issue 7, Pages 731–735, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/bc.2010.094, May 2010

Publication History

Published Online:


Ten years after the determination of the RNA polymerase II structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed.

Keywords: gene transcription and regulation; integrated structural biology; molecular systems biology; RNA polymerase; yeast

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Vladimir Svetlov and Evgeny Nudler
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013, Volume 1829, Number 1, Page 20
Dirk W. Heinz, Christian Betzel, and Matthias Wilmanns
Biological Chemistry, 2010, Volume 391, Number 7

Comments (0)

Please log in or register to comment.