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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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New insights into the phylogenetic distribution and evolutionary origins of the septins

Ryuichi Nishihama1 / Masayuki Onishi1 / 1

1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA

Corresponding author

Citation Information: Biological Chemistry. Volume 392, Issue 8-9, Pages 681–687, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2011.086, August 2011

Publication History



Until recently, it had appeared that the septin family of proteins was restricted to the opisthokont eukaryotes (the fungi and animals and their close relatives the microsporidia and choanoflagellates). It has now become apparent that septins are also present in several other widely divergent eukaryotic lineages (chlorophyte algae, brown algae, and ciliates). This distribution and the details of the non-opisthokont septin sequences appear to require major revisions to hypotheses about the origins and early evolution of the septins.

Keywords: brown algae; chlorophyte algae; ciliates; cytokinesis; green algae; guanine-nucleotide-binding proteins

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