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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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The mother-bud neck as a signaling platform for the coordination between spindle position and cytokinesis in budding yeast

Laura Merlini1 / 1, 2

1Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, I-20126 Milan, Italy

2Centre de Recherche en Biochimie Macromoléculaire, 1919 Route de Mende, F-34293 Montpellier, France

Corresponding author

Citation Information: Biological Chemistry. Volume 392, Issue 8-9, Pages 805–812, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2011.090, August 2011

Publication History

Received:
2011-05-03
Accepted:
2011-07-02

Abstract

During asymmetric cell division, spindle positioning is critical for ensuring the unequal inheritance of polarity factors. In budding yeast, the mother-bud neck determines the cleavage plane and a correct nuclear division between mother and daughter cell requires orientation of the mitotic spindle along the mother-bud axis. A surveillance device called the spindle position/orientation checkpoint (SPOC) oversees this process and delays mitotic exit and cytokinesis until the spindle is properly oriented along the division axis, thus ensuring genome stability. Cytoskeletal proteins called septins form a ring at the bud neck that is essential for cytokinesis. Furthermore, septins and septin-associated proteins are implicated in spindle positioning and SPOC. In this review, we discuss the emerging connections between septins and the SPOC and the role of the mother-bud neck as a signaling platform to couple proper chromosome segregation to cytokinesis.

Keywords: budding yeast; cytokinesis; mitotic exit; septins; spindle position checkpoint; spindle positioning

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