Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred


SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4315
See all formats and pricing

 


 
 

Select Volume and Issue
Loading journal volume and issue information...

Epigenetic regulation of kallikrein-related peptidases: there is a whole new world out there

Maria D. Pasic1 / Ekaterina Olkhov1, 2 / Bharati Bapat1, 2 / 1, 3

1Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King’s College Circle, Toronto M5S-1A8, Ontario, Canada

2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Toronto M5T-3L9, Ontario, Canada

3Department of Laboratory Medicine, and the Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael’s Hospital, 30 Bond Street, Toronto M5B-1W8, Ontario, Canada

Corresponding author

Citation Information: . Volume 393, Issue 5, Pages 319–330, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/hsz-2011-0273, May 2012

Publication History

Received:
2011-11-21
Accepted:
2012-01-20

Abstract

The human kallikreins are a cluster of 15 kallikreins and kallikrein-related peptidases (KLKs). Evidence shows the involvement of KLKs in a wide range of pathophysiological processes, and underscores their potential contribution to cancer, skin and neurodegenerative disorders. The control of KLK expression is not fully elucidated. Understanding the mechanisms controlling KLK expression is an essential step towards exploring the pathogenesis of several diseases and the use of KLKs as disease biomarkers and/or therapeutic targets. Recently, epigenetic changes (including methylation, histone modification and microRNAs [miRNAs]) have drawn attention as a new dimension for controlling KLK expression. Reports showed the effect of methylation on the expression of KLK genes. This was also shown to have potential utility as a prognostic marker in cancer. miRNAs are small RNAs that control the expression of their targets at the post-transcriptional level. Target prediction showed that KLKs are potential targets of miRNAs that are dysregulated in tumors, including prostate, kidney and ovarian cancers, with downstream effect on tumor proliferation. Experimental validation remains an essential step to confirm the KLK-miRNA interaction. Epigenetic regulation of KLKs holds promise for an array of therapeutic applications in many diseases including cancer.

Keywords: cancer; epigenetic; histone; kallikrein; methylation; miRNA

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Maria D Pasic, Georgia Sotiropoulou, and George M Yousef
Cell Cycle, 2015, Volume 14, Number 5, Page 691
[3]
Vittore Cereda, Vincenzo Formica, Antonello Menghi, Stefania Pellicori, and Mario Roselli
Expert Opinion on Investigational Drugs, 2015, Volume 24, Number 7, Page 929
[4]
Andrea Grin, Sara Samaan, Monika Tripathi, Fabio Rotondo, Kalman Kovacs, Mena N. Bassily, and George M. Yousef
Human Pathology, 2015, Volume 46, Number 4, Page 541
[5]
Andreas Scorilas and Konstantinos Mavridis
Expert Review of Molecular Diagnostics, 2014, Volume 14, Number 6, Page 713
[6]
Konstantinos Mavridis, Margaritis Avgeris, and Andreas Scorilas
Expert Opinion on Therapeutic Targets, 2014, Volume 18, Number 4, Page 365
[7]
Julia Dorn, Nathalie Beaufort, Manfred Schmitt, Eleftherios P. Diamandis, Peter Goettig, and Viktor Magdolen
Critical Reviews in Clinical Laboratory Sciences, 2014, Volume 51, Number 2, Page 63
[8]
J. Dorn, J. Bayani, G. M. Yousef, F. Yang, V. Magdolen, M. Kiechle, E. P. Diamandis, and M. Schmitt
Thrombosis and Haemostasis, 2013, Volume 110, Number 3, Page 408
[9]
Cheng-gui Miao, Ying-ying Yang, Xu He, and Jun Li
Cellular Signalling, 2013, Volume 25, Number 4, Page 875
[10]
Heba W.Z. Khella, Marize Bakhet, Zsuzsanna Lichner, Alexander D. Romaschin, Michael A.S. Jewett, and George M. Yousef
American Journal of Kidney Diseases, 2013, Volume 61, Number 5, Page 798

Comments (0)

Please log in or register to comment.