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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Ubiquilins in the crosstalk among proteolytic pathways

Dong Yun Lee1 / 1

1Department of Microbial Pathogenesis, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA

Corresponding author

Citation Information: . Volume 393, Issue 6, Pages 441–447, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/hsz-2012-0120, June 2012

Publication History

Received:
2012-02-11
Accepted:
2012-03-21

Abstract

Protein degradation occurs through several distinct proteolytic pathways for membrane and cytosolic proteins. There is evidence that these processes are linked and that crosstalk among these major protein degradation pathways occurs. Ubiquilins, a family of ubiquitin-binding proteins, are involved in all protein degradation pathways. This minireview provides an overview of ubiquilin function in protein degradation and contrasts it with sequestosome-1 (p62), a protein that also has been implicated in multiple proteolytic pathways.

Keywords: autophagy; lysosome; p62; proteasome

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