Editor-in-Chief: Jollès, Pierre / Mansuy, Isabelle
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Volume 3 (2012)
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Most Downloaded Articles
- Seven essential questions on G-quadruplexes by König, Sebastian L.B./ Evans, Amanda C. and Huppert, Julian L.
- Mitochondrial DNA: a blind spot in neuroepigenetics by Manev, Hari/ Dzitoyeva, Svetlana and Chen, Hu
- RNA regulons and the RNA-protein interaction network by Imig, Jochen/ Kanitz, Alexander and Gerber, AndréP.
- Peptide-based rotaxanes and catenanes: an emerging class of supramolecular chemistry systems by Moretto, Alessandro/ Crisma, Marco/ Formaggio, Fernando and Toniolo, Claudio
Seven essential questions on G-quadruplexes
1Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK
2Ecole Supérieure de Biotechnologie de Strasbourg (ESBS) Boulevard Sébastien Brandt, 67412 Illkirch-Graffenstaden, France
Citation Information: BioMolecular Concepts. Volume 1, Issue 2, Pages 197–213, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: 10.1515/bmc.2010.011, June 2010
- Published Online:
The helical duplex architecture of DNA was discovered by Francis Crick and James Watson in 1951 and is well known and understood. However, nucleic acids can also adopt alternative structural conformations that are less familiar, although no less biologically relevant, such as the G-quadruplex. G-quadruplexes continue to be the subject of a rapidly expanding area of research, owing to their significant potential as therapeutic targets and their unique biophysical properties. This review begins by focusing on G-quadruplex structure, elucidating the intermolecular and intramolecular interactions underlying its formation and highlighting several substructural variants. A variety of methods used to characterize these structures are also outlined. The current state of G-quadruplex research is then addressed by proffering seven pertinent questions for discussion. This review concludes with an overview of possible directions for future research trajectories in this exciting and relevant field.