Editor-in-Chief: Jollès, Pierre / Mansuy, Isabelle
Editorial Board Member: Avila, Jesus / Bollen, Mathieu / Bonetto, Valentina / Cera, Enrico / Jorgensen, Erik / Jörnvall, Hans / Lagasse, Eric / Norman, Robert / Pinna, Lorenzo / Raghavan, K. Vijay / Venetianer, Pal / Wahli, Walter
6 Issues per year
Volume 3 (2012)
Volume 2 (2011)
Most Downloaded Articles
- Seven essential questions on G-quadruplexes by König, Sebastian L.B./ Evans, Amanda C. and Huppert, Julian L.
- Mitochondrial DNA: a blind spot in neuroepigenetics by Manev, Hari/ Dzitoyeva, Svetlana and Chen, Hu
- RNA regulons and the RNA-protein interaction network by Imig, Jochen/ Kanitz, Alexander and Gerber, AndréP.
- Peptide-based rotaxanes and catenanes: an emerging class of supramolecular chemistry systems by Moretto, Alessandro/ Crisma, Marco/ Formaggio, Fernando and Toniolo, Claudio
Human aldo-keto reductases: structure, substrate specificity and roles in tumorigenesis
1Department of Medical Microbiology, Immunology and Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, 913 N. Rutledge Street, Springfield, IL 62794, USA
Citation Information: BioMolecular Concepts. Volume 2, Issue 1-2, Pages 115–126, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: 10.1515/bmc.2011.010, March 2011
- Published Online:
The aldo-keto reductase (AKR) superfamily consists of over 150 protein members sharing similar structure and enzymatic activities. To date, 13 human AKRs have been identified, and they participate in xenobiotic detoxification, biosynthesis and metabolism. Increasing evidence suggests the involvement of human AKR proteins in cancer development, progression and treatment. Some proteins demonstrate multiple functional features in addition to being a reductase for carbonyl groups. This review article discusses the most recent progress made in the study of humans AKRs.