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Biomolecular Concepts

Editor-in-Chief: Jollès, Pierre / Mansuy, Isabelle

Editorial Board Member: Avila, Jesus / Bollen, Mathieu / Bonetto, Valentina / Cera, Enrico / Jorgensen, Erik / Jörnvall, Hans / Lagasse, Eric / Norman, Robert / Pinna, Lorenzo / Raghavan, K. Vijay / Venetianer, Pal / Wahli, Walter

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1 / Laurenţiu M. Popescu2, 3

1Section of Histology, Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G. Pieraccini 6, I-50139 Florence, Italy

2Department of Cellular and Molecular Medicine ‘Carol Davila’ University of Medicine and Pharmacy, P.O. Box 35-29, Bucharest 35, Romania

3Department of Advanced Studies, ‘Victor Babeş’ National Institute of Pathology, 99-101 Splaiul Independenţei, RO-050096 Bucharest, Romania

Corresponding author

Citation Information: BioMolecular Concepts. Volume 2, Issue 6, Pages 481–489, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: 10.1515/BMC.2011.039, December 2011

Publication History



Here, we review the history, morphology, immunohistochemical phenotype, and presumptive roles of a new type of interstitial tissue cells, formerly called interstitial Cajal-like cells (ICLC) and by 2010 named ‘telocytes’ (TC). Many different techniques have been used to characterize TC and provide their unequivocal identification: (i) in vitro, cultures and isolated cells; (ii) in situ, fixed specimens examined by light and fluorescence microscopy, transmission (TEM) and scanning electron microscopy, and electron tomography. TEM allowed sure identification and characterization of the most peculiar feature of TC: the long, thin, and convoluted prolongations named ‘telopodes’. An enormous variety of antibodies have been tested, but presently none are reliable to specifically label TC. TC have a mesenchymal origin and are resident connective tissue (stromal) cells. Possible identification with ‘already identified’ stromal cell types (fibroblasts, fibrocytes, fibroblast-like cells, and mesenchymal stromal cells) is discussed. We conclude that in adulthood, most of the TC have the morphology of fibrocytes. Apparently, immunocytochemistry suggests that a variety of TC populations showing different, likely organ-specific, immunophenotypes might exist. Several roles have been hypothesized for TC: mechanical roles, intercellular signaling, guiding and nursing of immature cells during organogenesis, and being themselves a pool of precursors for many of the mesenchyme-derived cells in adulthood; however, none of these roles have been proven yet. On the basis of the available data, we propose TC may be key players in organ regeneration and repair.

Keywords: fibroblasts; interstitial Cajal-like cells (ICLC); interstitial cells of Cajal (ICC); mesenchymal cells; telopodes

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