Editor-in-Chief: Jollès, Pierre / Jörnvall, Hans / Mansuy, Isabelle
null Avila, Jesus / Bollen, Mathieu / Bonetto, Valentina / Cera, Enrico / Jorgensen, Erik / Lagasse, Eric / Norman, Robert / Pinna, Lorenzo / Raghavan, K. Vijay / Venetianer, Pal / Wahli, Walter
6 Issues per year
1Infectious Diseases Group, Malaghan Institute of Medical Research, Wellington, New Zealand
Corresponding author
Citation Information: BioMolecular Concepts. Volume 3, Issue 1, Pages 13–20, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: 10.1515/bmc.2011.051, February 2012
Publication History:
Effective vaccination against intracellular pathogens, such as tuberculosis (TB), relies on the generation and maintenance of CD4 memory T cells. An incomplete understanding of the memory immune response has hindered the rational design of a new, more effective TB vaccine. This review discusses how the persistence of antigen, the location of memory cells, and their multifunctional ability shape the CD4 memory T cell response against TB.
Keywords: CD4; intracellular pathogen; T cell memory; tuberculosis; vaccine
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