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Biomolecular Concepts

Editor-in-Chief: Jollès, Pierre / Mansuy, Isabelle

Editorial Board Member: Avila, Jesus / Bollen, Mathieu / Bonetto, Valentina / Cera, Enrico / Jorgensen, Erik / Jörnvall, Hans / Lagasse, Eric / Norman, Robert / Pinna, Lorenzo / Raghavan, K. Vijay / Venetianer, Pal / Wahli, Walter

6 Issues per year

SCImago Journal Rank (SJR) 2014: 0.375
Source Normalized Impact per Paper (SNIP) 2014: 0.258
Impact per Publication (IPP) 2014: 0.931


Elastin biology and tissue engineering with adult cells

1 / Steven G. Wise2, 3 / Anthony S. Weiss3 / John J. Castellot Jr4 / David L. Kaplan1

1Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USA

2Heart Research Institute, Sydney, New South Wales, Australia

3Molecular Biosciences, University of Sydney, Sydney, New South Wales, Australia

4Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA

Corresponding author: Cassandra B. Saitow, Tufts University, Department of Biomedical Engineering, Medford, MA, 02155, USA

Citation Information: BioMolecular Concepts. Volume 4, Issue 2, Pages 173–185, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: 10.1515/bmc-2012-0040, January 2013

Publication History

Published Online:


The inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells.

Keywords: elastin; heparin; smooth muscle cell; vascular tissue engineering

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