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Y RNAs: recent developments
1School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
aThese authors contributed equally to this work.
Citation Information: BioMolecular Concepts. Volume 4, Issue 2, Pages 103–110, ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: 10.1515/bmc-2012-0050, January 2013
- Published Online:
Non-coding RNAs have emerged as key regulators in diverse cellular processes. Y RNAs are ∼100-nucleotide-long non-coding RNAs that show high conservation in metazoans. Human Y RNAs are known to bind to the Ro60 and La proteins to form the Ro ribonucleoprotein complex. Their main biological function appears to be in mediating the initiation of chromosomal DNA replication, regulating the autoimmune protein Ro60, and generating smaller RNA fragments following cellular stress, although the precise molecular mechanisms underlying these functions remain elusive. Here, we aim to review the most recent literature on Y RNAs and gain insight into the function of these intriguing molecules.
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