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Biomedical Engineering / Biomedizinische Technik

Editor-in-Chief: Dössel, Olaf

Editorial Board Member: Augat, Peter / Gehring, Hartmut / Haueisen, Jens / Jockenhoevel, Stefan / Kraft, Marc / Leonhardt, Steffen / Niederlag, Wolfgang / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Schmitz, Georg / Stieglitz, Thomas / Witte, Herbert / Boenick, Ulrich / Lenthe, Harry / Penzel, Thomas / Clasbrummel, Bernhard / Robitzki, Andrea A. / Snedeker, Jess G. / Wintermantel, Erich / Werner, Jürgen

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Volume 57 (2012)

Non-invasive simultaneous recording of neuronal and vascular signals in subacute ischemic stroke

1 / Tilmann Sander-Thoemmes2 / Heidrun Wabnitz2 / Michael Moeller2 / Michaela Wachs1 / Gabriel Curio1 / Rainer Macdonald2 / Lutz Trahms2 / Bruno-Marcel Mackert3

1Department of Neurology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany

2Departments of Biosignals and Biomedical Optics, Physikalisch-Technische Bundesanstalt, Berlin, Germany

3Department of Neurology, Vivantes Auguste Viktoria-Klinikum, Berlin, Germany

Corresponding author: Stefanie Leistner, Charité-University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany Phone: +49-30-8445-2276 Fax: +49-30-8445-4264

Citation Information: Biomedizinische Technik/Biomedical Engineering. Volume 56, Issue 2, Pages 85–90, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: 10.1515/bmt.2011.002, February 2011

Publication History

Received:
2010-06-28
Accepted:
2011-01-14
Published Online:
2011-02-07

Abstract

In acute focal cerebral ischemia blood flow and neuronal activity change dramatically. A better understanding of the pathophysiological interactions of these two important parameters is limited owing to the lack of noninvasive techniques to simultaneously measure these parameters in humans. In this feasibility study, we used DC-magnetoencephalography and near-infrared spectroscopy to find out whether blood flow and neuronal activity as well as neurovascular coupling can be analyzed in patients suffering from subacute ischemic stroke. In a simple motor test condition, six patients with subacute ischemic stroke performed self-paced finger movements (30-s periods of movement, separated by 30-s periods of rest; for a total of 15 min). Combined DC-magnetoencephalography and near-infrared spectroscopy were recorded over the affected and unaffected hemispheres. As a control group, four healthy subjects were investigated. In four out of six patients, the time courses of both signals closely followed the motor task cycles revealing significant differences between movement and rest periods. The vascular signal reached a maximum 1–5 s later than the neuronal signals. This proof-of-principle study demonstrates that it has become feasible to simultaneously and noninvasively monitor neuronal and vascular signal changes in patients in the subacute state of ischemic stroke.

Keywords: DC-magnetoencephalography; near-infrared spectroscopy; neurovascular coupling; stroke

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