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Biomedical Engineering / Biomedizinische Technik

Editor-in-Chief: Dössel, Olaf

Editorial Board Member: Augat, Peter / Gehring, Hartmut / Haueisen, Jens / Jockenhoevel, Stefan / Kraft, Marc / Leonhardt, Steffen / Niederlag, Wolfgang / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Schmitz, Georg / Stieglitz, Thomas / Witte, Herbert / Boenick, Ulrich / Lenthe, Harry / Penzel, Thomas / Clasbrummel, Bernhard / Robitzki, Andrea A. / Snedeker, Jess G. / Wintermantel, Erich / Werner, Jürgen

6 Issues per year

Increased IMPACT FACTOR 2013: 2.425
5-year IMPACT FACTOR: 1.307
Rank 6 out of 25 in category Medical Informatics and 25 out of 77 in category Biomedical Engineering in the 2013 Thomson Reuters Journal Citation Report/Science

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Volume 57 (2012)

Magnetic spectroscopy of nanoparticle Brownian motion measurement of microenvironment matrix rigidity

1–3, , / Kristen M. Rauwerdink1 / Adam M. Rauwerdink2 / Irina M. Perreard1

1Department of Radiology, Dartmouth Medical School and Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA

2Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA

3Department of Physics, Dartmouth College, Hanover, New Hampshire, USA

Corresponding author: John B. Weaver, PhD, Department of Radiology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA, Phone: +1 (603) 650-8270, E-mail: ;

Citation Information: Biomedizinische Technik/Biomedical Engineering. Volume 58, Issue 6, Pages 547–550, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: 10.1515/bmt-2013-0012, August 2013

Publication History

Received:
2013-01-31
Accepted:
2013-07-15
Published Online:
2013-08-14

Abstract

The rigidity of the extracellular matrix and of the integrin links to the cytoskeleton regulates signaling cascades, controlling critical aspects of cancer progression including metastasis and angiogenesis. We demonstrate that the matrix stiffness can be monitored using magnetic spectroscopy of nanoparticle Brownian motion (MSB). We measured the MSB signal from nanoparticles bound to large dextran polymers. The number of glutaraldehyde induced cross-links was used as a surrogate for material stiffness. There was a highly statistically significant change in the MSB signal with the number of cross-links especially prominent at higher frequencies. The p-values were all highly significant. We conclude that the MSB signal can be used to identify and monitor changes in the stiffness of the local matrix to which the nanoparticles are bound.

Keywords: magnetic nanoparticle spectroscopy; magnetization harmonics; relaxation times; rotational Brownian motion

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