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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Objectives, Design and Recruitment of a Familial and Longitudinal Cohort for Studying Gene-Environment Interactions in the Field of Cardiovascular Risk: The Stanislas Cohort

Gérard Siest / Sophie Visvikis / Bernard Herbeth / René Gueguen / Monique Vincent-Viry / Catherine Sass / Brigitte Beaud / Edith Lecomte / Josiane Steinmetz / Jean Locuty / Philippe Chevrier

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 36, Issue 1, Pages 35–42, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.1998.007, June 2005

Publication History

Published Online:
2005-06-01

Abstract

The main objective of the Stanislas cohort is to study the role and the contribution of genetic and environmental factors to cardiovascular status. We plan:

  • a)

    to describe the degree of association of a large number of cardiovascular risk indicators with cardiovascular endpoints,

  • b)

    to evaluate the contribution of genetic and that of environmental factors to this association,

  • c)

    to follow the evolution of these risk indicators during a period of at least ten years,

  • d)

    to search for the determinants influencing this evolution.

The principal variables studied are:

  • a)

    to describe the degree of association of a large number of cardiovascular risk indicators with cardiovascular endpoints,

  • b)

    to evaluate the contribution of genetic and that of environmental factors to this association,

  • c)

    to follow the evolution of these risk indicators during a period of at least ten years,

  • d)

    to search for the determinants influencing this evolution.

  • a)

    blood pressure, cardiac mass, and wall thickness of carotid and femoral arteries,

  • b)

    obesity and fat mass,

  • c)

    indicators of lipid metabolism,

  • d)

    genetic polymorphisms of several cardiovascular risk candidate genes,

  • e)

    food, tobacco and alcohol consumption,

  • f)

    consumption of drugs and anti-oxidant vitamins.

Between September 1993 and August 1995, 1006 families consisting of the two biological parents with at least two children were recruited totalling 4295 individuals. This cohort will be followed up until 2004. There will be two health examinations five and ten years after the initial examination. A bank of blood samples (serum and plasma) in liquid nitrogen and DNA (−80 °C) has been established.

Citing Articles

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[1]
Jean-Brice Marteau, Bernard Herbeth, Daniel Lambert, and Sophie Visvikis-Siest
Obesity Research, 2005, Volume 13, Number 10, Page 1845
[2]
H. Benachour, M. Zaiou, A. Samara, B. Herbeth, M. Pfister, D. Lambert, G. Siest, and S. Visvikis-Siest
Nutrition, Metabolism and Cardiovascular Diseases, 2009, Volume 19, Number 10, Page 720
[4]
Anastasia Samara, Bernard Herbeth, Ndeye Coumba Ndiaye, Fréderic Fumeron, Stéphanie Billod, Gérard Siest, and Sophie Visvikis-Siest
Nutrition, 2013, Volume 29, Number 3, Page 519
[5]
Marie Marduel, Khadija Ouguerram, Valérie Serre, Dominique Bonnefont-Rousselot, Alice Marques-Pinheiro, Knut Erik Berge, Martine Devillers, Gérald Luc, Jean-Michel Lecerf, Laurent Tosolini, Danièle Erlich, Gina M. Peloso, Nathan Stitziel, Patrick Nitchké, Jean-Philippe Jaïs, Marianne Abifadel, Sekar Kathiresan, Trond Paul Leren, Jean-Pierre Rabès, Catherine Boileau, and Mathilde Varret
Human Mutation, 2013, Volume 34, Number 1, Page 83
[6]
Bernard Herbeth, Anastasia Samara, Maria Stathopoulou, Gérard Siest, and Sophie Visvikis-Siest
Journal of Nutrition and Metabolism, 2012, Volume 2012, Page 1
[7]
Marianne Abifadel, Maryse Guerin, Suzanne Benjannet, Jean-Pierre Rabès, Wilfried Le Goff, Zélie Julia, Josée Hamelin, Valérie Carreau, Mathilde Varret, Eric Bruckert, Laurent Tosolini, Olivier Meilhac, Philippe Couvert, Dominique Bonnefont-Rousselot, John Chapman, Alain Carrié, Jean-Baptiste Michel, Annik Prat, Nabil G. Seidah, and Catherine Boileau
Atherosclerosis, 2012, Volume 223, Number 2, Page 394
[10]
S. Maumus, G. Siest, and S. Visvikis-Siest
Annales Pharmaceutiques Françaises, 2007, Volume 65, Number 3, Page 211
[11]
P. Lemoine, A. Sassolas, C. Lestra, L. Laforest, and G. Chamba
L'Encéphale, 2004, Volume 30, Number 4, Page 360
[12]
Hind Berrahmoune, Bernard Herbeth, John V. Lamont, Peter S. Fitzgerald, and Sophie Visvikis-Siest
Atherosclerosis, 2007, Volume 192, Number 2, Page 348
[13]
Elise Jeannesson, Gérard Siest, Bérangère Bastien, Laetitia Albertini, Charalampos Aslanidis, Gerd Schmitz, and Sophie Visvikis-Siest
Clinica Chimica Acta, 2009, Volume 403, Number 1-2, Page 198
[14]
Gérard Siest, Jean-Brice Marteau, Sandy Maumus, Hind Berrahmoune, Elise Jeannesson, Anastasia Samara, Anne-Marie Batt, and Sophie Visvikis-Siest
European Journal of Pharmacology, 2005, Volume 527, Number 1-3, Page 1
[15]
Ricarda Thier, Thomas Brüning, Peter H. Roos, Hans-Peter Rihs, Klaus Golka, Yon Ko, and Hermann M. Bolt
International Journal of Hygiene and Environmental Health, 2003, Volume 206, Number 3, Page 149
[16]
Maggie C.Y Ng, Ying Wang, Wing-Yee So, Suzanne Cheng, Sophie Visvikis, Robert Y.L Zee, Arturo Fernandez-Cruz, Klaus Lindpaintner, and Juliana C.N Chan
Genomics, 2004, Volume 83, Number 4, Page 559
[17]
F. Schiele, D. De Bacquer, M. Vincent-Viry, U. Beisiegel, C. Ehnholm, A. Evans, A. Kafatos, M.C. Martins, S. Sans, C. Sass, S. Visvikis, G. De Backer, and G. Siest
Atherosclerosis, 2000, Volume 152, Number 2, Page 475
[18]
Elise Jeannesson, Gerard Siest, Bernard Herbeth, Laetitia Albertini, Payman Shahabi, Michele Pfister, and Sophie Visvikis-Siest
Drug Metabolism and Drug Interactions, 2011, Volume 26, Number 1
[19]
Catherine Sass, Suzanne Cheng, Gérard Siest, and Sophie Visvikis
Journal of Hypertension, 2004, Volume 22, Number 2, Page 297
[20]
Catherine Sass, Bernard Herbeth, Gérard Siest, and Sophie Visvikis
Journal of Hypertension, 2000, Volume 18, Number 12, Page 1775
[21]
Philippe Bertrand, Marjorie Starck, Bernard Herbeth, Monique Vincent-Viry, Françoise Schiele, and Gérard Siest
Clinical Chemistry and Laboratory Medicine, 2002, Volume 40, Number 8
[22]
G Siest, E Jeannesson, H Berrahmoune, S Maumus, J-B Marteau, S Mohr, and S Visvikis
Pharmacogenomics, 2004, Volume 5, Number 7, Page 779
[23]
C. Bertrand-Thiébault, H. Berrahmoune, A. Thompson, B. Marie, S. Droesch, G. Siest, D. Foernzler, and S. Visvikis-Siest
Annals of Human Genetics, 2008, Volume 72, Number 2, Page 178
[24]
Stephen C. Stearns, Sean G. Byars, Diddahally R. Govindaraju, and Douglas Ewbank
Nature Reviews Genetics, 2010
[25]
C Pallaud, C Sass, F Zannad, G Siest, and S Visvikis
Clinical Genetics, 2002, Volume 59, Number 5, Page 316
[26]
Anastasia Samara, Bernard Herbeth, Roberte Aubert, Hind Berrahmoune, Frédéric Fumeron, Gérard Siest, and Sophie Visvikis-Siest
Obesity, 2010, Volume 18, Number 1, Page 196
[27]
Nicolas Gambier, Jean-Brice Marteau, Anne-Marie Batt, Bérangère Marie, Annick Thompson, Gérard Siest, Dorothee Foernzler, and Sophie Visvikis-Siest
Journal of Hypertension, 2006, Volume 24, Number 11, Page 2199
[28]
P. E. Morange, D. A. Tregouet, C. Frere, N. Saut, L. Pellegrina, M. C. Alessi, S. Visvikis, L. Tiret, and I. Juhan-Vague
British Journal of Haematology, 2005, Volume 128, Number 1, Page 91
[29]
Anastasia Samara, Michèle Pfister, Berangère Marie, and Sophie Visvikis-Siest
Clinical Endocrinology, 2008, Volume 69, Number 4, Page 568
[30]
H Berrahmoune, B Herbeth, A Samara, J-B Marteau, G Siest, and S Visvikis-Siest
International Journal of Obesity, 2008, Volume 32, Number 8, Page 1279
[31]
J. B. MARTEAU, D. LAMBERT, B. HERBETH, B. MARIE, S. DROESCH, D. A. TREGOUET, and S. VISVIKIS-SIEST
Journal of Thrombosis and Haemostasis, 2008, Volume 6, Number 6, Page 920
[32]
Elise Jeannesson, Laetitia Albertini, Gérard Siest, Ana-Margarida Gomes, Vera Ribeiro, Charalampos Aslanidis, Gerd Schmitz, and Sophie Visvikis-Siest
Fundamental & Clinical Pharmacology, 2007, Volume 21, Number 4, Page 411
[33]
H Berrahmoune, B Herbeth, G Siest, and S Visvikis-Siest
Genes and Immunity, 2007, Volume 8, Number 4, Page 352
[34]
Hind Berrahmoune, Bernard Herbeth, John V. Lamont, Christine Masson, Peter S. Fitzgerald, and Sophie Visvikis-Siest
Annals of Human Genetics, 2007, Volume 71, Number 1, Page 54
[35]
Hind Berrahmoune, Bernard Herbeth, John V Lamont, Christine Masson, Stephen P FitzGerald, and Sophie Visvikis-Siest
Journal of Investigative Dermatology, 2007, Volume 127, Number 4, Page 969
[36]
N Gambier, A-M Batt, B Marie, M Pfister, G Siest, and S Visvikis-Siest
The Pharmacogenomics Journal, 2005, Volume 5, Number 4, Page 271
[37]
O. Mammes, R. Aubert, D. Betoulle, F. Pean, B. Herbeth, S. Visvikis, G. Siest, and F. Fumeron
European Journal of Clinical Investigation, 2001, Volume 31, Number 5, Page 398
[38]
F Zannad, C Sass, and S Visvikis
Clinical and Experimental Pharmacology and Physiology, 2001, Volume 28, Number 12, Page 1007
[39]
Mariza de Andrade, Ren� Gu�guen, Sophie Visvikis, Catherine Sass, G�rard Siest, and Christopher I. Amos
Genetic Epidemiology, 2002, Volume 22, Number 3, Page 221

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