The Biochemistry of Gene Therapy for AIDS : Clinical Chemistry and Laboratory Medicine Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

30,00 € / $42.00 / £23.00

Get Access to Full Text

The Biochemistry of Gene Therapy for AIDS

Andrea Savarino / Gian Piero Pescarmona / Emilia Turco / Phalguni Gupta

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 36, Issue 4, Pages 205–210, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.1998.035, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Gene therapy has enormous potential and could in the near future involve the clinical biochemist in monitoring its efficacy. The involvement of clinical biochemists in this field could be not only in evaluating the impact of a gene-based strategy on disease progression, but also in measuring the expression of the products of therapeutic genes in treated individuals. Indeed, gene therapy presents new possibilities for the treatment of many diseases and, in particular, merits consideration in the treatment of a fatal disease like AIDS. The aim of this paper is to review the biochemical basis and clinical relevance of the gene therapy approaches directed towards the inhibition of human immunodeficiency virus type-1. We discuss the goals which have been achieved, the problems which have occurred and the efforts that are being made to solve them. In this regard, particular attention is paid to new strategies targeting ‘therapeutic’ enzymes to human immunodeficiency virus type-1 nucleic acids.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
AIDS Patient Care and STDs, 1999, Volume 13, Number 3, Page 207
[2]
Noriyasu Sakai, Koichi Miyake, Noriko Suzuki, and Takashi Shimada
International Journal of Hematology, 2001, Volume 73, Number 4, Page 476
[3]
Andrea Savarino
Expert Opinion on Investigational Drugs, 2006, Volume 15, Number 12, Page 1507
[4]
Andrea Savarino, Gian Piero Pescarmona, and Johan R. Boelaert
Cell Biochemistry and Function, 1999, Volume 17, Number 4, Page 279

Comments (0)

Please log in or register to comment.