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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition



Long-Term Variability of Serum Lipoprotein(a) Concentrations in Healthy Fertile Women

Roselyne Garnotel / Frédérique Monier / Fabrice Lefèvre / Philippe Gillery

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 36, Issue 5, Pages 317–321, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.1998.053, June 2005

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Lipoprotein(a) is a unique lipoprotein with atherothrombogenic properties. Although its blood concentration is mainly genetically determined, various factors exist which may cause variability. These may influence the clinical use of the results. We studied lipoprotein(a) biological variation by a rate nephelometric assay over a period of two years in a population of healthy fertile women. The study was performed in 12 volunteers, healthy subjects with various lipoprotein( a) concentrations, by monthly determinations during one year and a single determination one year later, together with measurements of total, high density lipoprotein and high density lipoprotein2 cholesterol, triglycerides and apolipoproteins A1 and B. The intra-individual variability of lipoprotein(a) ranged between 4 to 20%, with three subjects showing a coefficient of biological variation higher than 15 %. In absolute terms, the difference between two determinations could represent 0.44 g/l or 50 % of the mean value. This study suggests that physiological lipoprotein( a) variations should be taken into account for clinical purposes, especially in patients in need of thorough risk evaluation.

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