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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

13 Issues per year


IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR): 0.860
Source Normalized Impact per Paper (SNIP): 1.046

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Does the Uncertainty of Commonly Performed Glucose Measurements Allow Identification of Individuals at High Risk for Diabetes?

Anders Kallner / Johan Waldenström

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 37, Issue 9, Pages 907–912, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.1999.134, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Revised recommendations for diagnosis of diabetes introduce the intermediary risk group of impaired fasting glucose (IFG), defined as individuals with a fasting blood-glucose concentration between 5.6 and 6.0 mmol/l. We apply the concept of uncertainty to identifiable steps of sampling and measuring blood-glucose. Since many instruments in primary health care measure plasma-glucose and report results as blood-glucose and vice versa, factors affecting the transformation are also considered. The study identifies the measurement procedure as the major source of uncertainty, closely followed by preanalytical sources. The estimated uncertainties indicate that the presently available procedures do not allow identification of IFG by a single investigation. The approach to establish an uncertainty budget can be used to evaluate the clinical usefulness of measurements.

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