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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Evaluation of a Fully Automated Assay to Measure C-Telopeptide of Type I Collagen in Serum

Franca Pagani / Graziella Bonetti / Francesca Stefini / Mauro Panteghini

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 38, Issue 11, Pages 1111–1113, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2000.166, June 2005

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The measurement of the degradation product of the C-telopeptide of type I collagen in serum (s-βCTX) has been evaluated in the form of an automated chemiluminometric assay. The between-day coefficients of variation ranged between 2.6 and 6.0% over the concentration range 0.12 to 3.25 μg/l. The s-βCTX value correlated well with alternative serum C-telopeptide (r = 0.983) and urine deoxypyridinoline (r = 0.729) measurements. A significant inverse correlation was found between the s-βCTX measurement and creatinine clearance in patients with renal disease.

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