Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year


IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR): 0.860
Source Normalized Impact per Paper (SNIP): 1.046

VolumeIssuePage

Issues

Transforming Growth Factor-β1 as a Surrogate Marker of Hepatic Dysfunction in Chronic Liver Diseases

Robert Flisiak / Danuta Prokopowicz

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 38, Issue 11, Pages 1129–1131, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2000.170, June 2005

Publication History

Published Online:
2005-06-01

Abstract

The aim of the study was to evaluate the possible association between plasma concentrations of transforming growth factor-β1 (TGF-β1) and the degree of hepatic dysfunction in patients with chronic liver diseases. TGF-β1 was measured with an enzyme immunoassay in plasma from 21 patients with chronic active hepatitis and 40 patients with liver cirrhosis. Normal values were obtained from a group of 13 healthy volunteers. Results were analysed with respect to aetiology and the degree of liver insufficiency as evaluated by the Child-Pugh classification. The mean plasma concentration of TGF-β1in patients 36.9±2.8 ng/ml) was twice that found in normal volunteers (18.3±1.6 ng/ml). The highest values were observed in patients with alcoholic liver cirrhosis (44.4±4.7 ng/ml). Plasma TGF-β1 showed a statistically significant positive correlation with the degree of liver insufficiency. These results indicate the possible use of plasma TGF-β1 measurement as a good marker of liver function impairment. Further observation of patients involved in this study may help to evaluate its possible prognostic value in chronic liver diseases.

Comments (0)

Please log in or register to comment.