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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year

IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR): 0.860
Source Normalized Impact per Paper (SNIP): 1.046



Transforming Growth Factor-β1 as a Surrogate Marker of Hepatic Dysfunction in Chronic Liver Diseases

Robert Flisiak / Danuta Prokopowicz

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 38, Issue 11, Pages 1129–1131, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2000.170, June 2005

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The aim of the study was to evaluate the possible association between plasma concentrations of transforming growth factor-β1 (TGF-β1) and the degree of hepatic dysfunction in patients with chronic liver diseases. TGF-β1 was measured with an enzyme immunoassay in plasma from 21 patients with chronic active hepatitis and 40 patients with liver cirrhosis. Normal values were obtained from a group of 13 healthy volunteers. Results were analysed with respect to aetiology and the degree of liver insufficiency as evaluated by the Child-Pugh classification. The mean plasma concentration of TGF-β1in patients 36.9±2.8 ng/ml) was twice that found in normal volunteers (18.3±1.6 ng/ml). The highest values were observed in patients with alcoholic liver cirrhosis (44.4±4.7 ng/ml). Plasma TGF-β1 showed a statistically significant positive correlation with the degree of liver insufficiency. These results indicate the possible use of plasma TGF-β1 measurement as a good marker of liver function impairment. Further observation of patients involved in this study may help to evaluate its possible prognostic value in chronic liver diseases.

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